Cyclic Peptides in Pipeline: What Future for These Great Molecules?

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Costa, L (Author) Other; Sousa, E (Author) Other; Carla Fernandes (Author) FFUP

Journal

Title: Pharmaceuticals

Vol. 12

Final page: 996

ISSN: 1424-8247

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-TKZ

DOI: 10.3390/ph16070996

Abstract (EN): Cyclic peptides are molecules that are already used as drugs in therapies approved for various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and immunosuppressants. Interest in these molecules has been growing due to the improved pharmacokinetic and pharmacodynamic properties of the cyclic structure over linear peptides and by the evolution of chemical synthesis, computational, and in vitro methods. To date, 53 cyclic peptides have been approved by different regulatory authorities, and many others are in clinical trials for a wide diversity of conditions. In this review, the potential of cyclic peptides is presented, and general aspects of their synthesis and development are discussed. Furthermore, an overview of already approved cyclic peptides is also given, and the cyclic peptides in clinical trials are summarized.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 35