Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
Publication

Publications

TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD

Title
TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
Type
Article in International Scientific Journal
Year
2023
Authors
Lousa, I
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Reis, F
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Viana, S
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Vieira, P
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Vala, H
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. View Authenticus page Without ORCID
Belo, L
(Author)
FFUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page Without ORCID
Alice Santos Silva
(Author)
FFUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Journal
Title: BiomoleculesImported from Authenticus Search for Journal Publications
Vol. 13
Final page: 534
ISSN: 2218-273X
Publisher: MDPI
Indexing
Other information
Authenticus ID: P-00Y-3AA
Abstract (EN): The inflammatory pathway driven by TNF-alpha, through its receptors TNFR1 and TNFR2, is a common feature in the pathogenesis of chronic kidney disease (CKD), regardless of the initial disease cause. Evidence correlates the chronic inflammatory status with decreased renal function. Our aim was to evaluate the potential of TNF receptors as biomarkers for CKD diagnosis and staging, as well as their association with the progression of renal lesions, in rat models of early and moderate CKD. We analyzed the circulating levels of inflammatory molecules-tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor receptor 1 (TNFR1) and 2 (TNFR2) and tissue inhibitor of metalloproteinase-1 (TIMP-1)-and studied their associations with TNFR1 and TNFR2 renal expression, glomerular and tubulointerstitial lesions, and with biomarkers of renal (dys)function. An increase in all inflammatory markers was observed in moderate CKD, as compared to controls, but only circulating levels of both TNFR1 and TNFR2 were significantly increased in the early disease; TNFR2 serum levels were negatively correlated with eGFR. However, only TNFR2 renal expression increased with CKD severity and showed correlations with the score of mild and advanced tubular lesions. Our findings suggest that renal TNFR2 plays a role in CKD development, and has potential to be used as a biomarker for the early detection and progression of the disease. Still, the potential value of this biomarker in disease progression warrants further investigation.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 14
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis (2024)
Another Publication in an International Scientific Journal
Martins, D; Silva, C; Ferreira, AC; Dourado, S; Albuquerque, A; Saraiva, F; Batista, AB; Pedro Castro; Leite-Moreira, A; Barros, AS; miranda, im
Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy? (2023)
Another Publication in an International Scientific Journal
Ramos, V; Reis, M; Ferreira, L; Silva, AM; Ferraz, R; Vieira, M; Vitor Vasconcelos; Martins, R
Natural Sympathomimetic Drugs: From Pharmacology to Toxicology (2022)
Another Publication in an International Scientific Journal
Costa, VM; Grando, LGR; Milandri, E; Nardi, J; Teixeira, P; Mladenka, P; Fernando Remiao
Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems (2020)
Another Publication in an International Scientific Journal
Baldim, I; Oliveira, WP; Kadian, V; Rao, R; Yadav, N; Mahant, S; Lucarini, M; Durazzo, A; Da Ana, R; Capasso, R; Souto, SB; Santini, A; Souto, EB
Mucin-Type O-Glycosylation in Gastric Carcinogenesis (2016)
Another Publication in an International Scientific Journal
Duarte, HO; Freitas, D; Gomes, C; Gomes, J; Magalhaes, A; Celso Reis

See all (58)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-08-08 at 21:55:37 | Privacy Policy | Personal Data Protection Policy | Whistleblowing