Reinforced Portland cement porous scaffolds for load-bearing bone tissue engineering applications

• Type: Article in International Scientific Journal
• Date: 2012

Authors

N Higuita-Castro (Author) Other; GAllego-Perez D (Author) Other; Alejandro Vargas (Author) FEUP; García Quiroz F (Author) Other; Posada OM (Author) Other; López LE (Author) Other; Sarassa CA (Author) Other; Agudelo-Florez P (Author) Other; Fernando Mendes Monteiro (Author) FEUP; Litsky AS (Author) Other; Derek Hansford (Adapter) FEUP

Journal

Title: Journal of Biomedical Materials Research - Part B Applied Biomaterials

Vol. 100B

Pages: 501-507

ISSN: 1552-4973

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 5 Citations

ISI Web of Science

Scopus - 6 Citations

Scientific classification

FOS: Engineering and technology

CORDIS: Technological sciences

Other information

Authenticus ID: P-002-DPJ

DOI: 10.1002/jbm.b.31976

Abstract (EN): Modified Portland cement porous scaffolds with suitable characteristics for load-bearing bone tissue engineering applications were manufactured by combining the particulate leaching and foaming methods. Non-crosslinked polydimethylsiloxane was evaluated as a potential reinforcing material. The scaffolds presented average porosities between 70 and 80% with mean pore sizes ranging from 300 mu m up to 5.0 mm. Non-reinforced scaffolds presented compressive strengths and elastic modulus values of 2.6 and 245 MPa, respectively, whereas reinforced scaffolds exhibited 4.2 and 443 MPa, respectively, an increase of similar to 62 and 80%. Portland cement scaffolds supported human osteoblast-like cell adhesion, spreading, and propagation (t = 128 days). Cell metabolism and alkaline phosphatase activity were found to be enhanced at longer culture intervals (t = 14 days). These results suggest the possibility of obtaining strong and biocompatible scaffolds for bone repair applications from inexpensive, yet technologically advanced materials such as Portland cement. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 501507, 2012.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7