Exploring the Mutual Information Rate Decomposition in Situations of Pathological Stress

• Type: Article in International Conference Proceedings Book
• Date: 2025

Authors

Pinto, H (Author) FCUP; dias, c (Author) FMUP; Barà, C (Author) Other; Antonacci, Y (Author) Other; Faes, L (Author) Other; Rocha, AP (Author) FCUP

Conference proceedings International

Title: Springer Proceedings in Mathematics and Statistics

Pages: 243-257

26th Congress of the Portuguese Statistical Society, SPE 2023

Evora, 13 October 2021 through 16 October 2021

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-017-SJW

DOI: 10.1007/978-3-031-68949-9_18

Abstract (EN): A Plateau wave (PW) represents a distinctive pattern of Intracranial Pressure (ICP) change observed in patients with severe traumatic brain injuries (TBI), marked by a sudden sustained increase in ICP. These pathological stress events are frequently linked with significant alterations in Heart Rate Variability (HRV), indicative of Autonomic Nervous System (ANS) dysfunction. This study aims to investigate the coupling between ICP and HRV by employing the Mutual Information Rate (MIR). MIR serves as an extension of Mutual Information (MI), enabling the analysis of the dynamic exchange of information across various time intervals. Furthermore, the MIR between two random processes can be decomposed into distinct entropy rate components associated with the concept of complexity, as well as conditional mutual information terms related to information transfer. The MIR and its constituent information terms are estimated through a model-free approach based on the nearest neighbors search (KNN). This framework is first validated on simulations of linear and non-linear bivariate systems, then it is applied to data consisting of RR intervals and ICP amplitude (AMP) time series measured in TBI patients with PW occurrence. The obtained results evidence that MIR decompositions are able to highlight the interdependence of HRV and ICP in PW episodes and the association of these critical phenomena with autonomic stress. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14