The Effect of Oxygen and Glucose in the Cell Proliferation Process Analysed with a Meshless Method

• Type: Article in International Conference Proceedings Book
• Date: 2023

Authors

Barbosa, MIA (Author) Other; Belinha, J (Author) Other; Renato Natal Jorge (Author) FEUP; Carvalho, AX (Author) Other

Conference proceedings International

Title: Lecture Notes in Bioengineering

Pages: 423-431

10th Congress of the Portuguese Society of Biomechanics, CNB 2023

Figueira da Foz, 5 May 2023 through 6 May 2023

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-010-6E3

DOI: 10.1007/978-3-031-47790-4_41

Abstract (EN): To ensure that the cell function is performed correctly, the availability of oxygen and nutrients in the extracellular environment must be adequate. One of the most important functions that cells perform is the capacity to proliferate, which is deeply affected by the concentration of these factors. Like normal healthy cells, tumour cells are also dependent on these and their abnormal proliferation can be enhanced or negatively affected under the presence of specific concentrations. The objective of the present work was to implement and verify how oxygen and glucose concentrations affect the process of cell proliferation in healthy and tumour cells. To do that, a new iterative discrete algorithm proposed by the authors was used. In this algorithm, the meshless method Radial Point Interpolation Method and a new phenomenological growth law, also proposed by the authors, were combined. Moreover, for both normal and tumour cells different ranges of glucose and oxygen concentration were tested and the evolution of the volume of the cells along the time was analysed. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8