Chiral separation by SMB chromatography

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Luís S. Pais (Author) Other; José M. Loureiro (Author) FEUP; Alírio E. Rodrigues (Author) FEUP

Journal

Title: Separation and Purification Technology

Vol. 20 No. 1

Pages: 67-77

ISSN: 1383-5866

Publisher: Elsevier

Indexing

ISI Web of Science

COMPENDEX

Scientific classification

CORDIS: Technological sciences > Technology > Biotecnology > Downstream processing ; Physical sciences > Chemistry > Analytical chemistry > Spectrochemistry ; Physical sciences > Mathematics > Computational mathematics > Computational models

Other information

DOI: 10.1016/S1383-5866(00)00063-0

Abstract (EN): The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles. The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles. (C) 2000 Elsevier Science B.V. All rights reserved.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11