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Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

Title
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis
Type
Article in International Scientific Journal
Year
2014
Authors
Melo, SA
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Sugimoto, H
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O'Connell, JT
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Kato, N
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Villanueva, A
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Vidal, A
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Qiu, L
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Vitkin, E
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Perelman, LT
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Melo, CA
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Lucci, A
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Ivan, C
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Calin, GA
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Kalluri, R
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Journal
Title: Cancer CellImported from Authenticus Search for Journal Publications
Vol. 26
Pages: 707-721
ISSN: 1535-6108
Publisher: Elsevier
Other information
Authenticus ID: P-00A-077
Abstract (EN): Exosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we report that breast cancer associated exosomes contain microRNAs (miRNAs) associated with the RISC-Loading Complex (RLC) and display cell-independent capacity to process precursor microRNAs (pre-miRNAs) into mature miRNAs. Pre-miRNAs, along with Dicer, AGO2, and TRBP, are present in exosomes of cancer cells. CD43 mediates the accumulation of Dicer specifically in cancer exosomes. Cancer exosonnes mediate an efficient and rapid silencing of mRNAs to reprogram the target cell transcriptome. Exosomes derived from cells and sera of patients with breast cancer instigate nontumorigenic epithelial cells to form tumors in a Dicer-dependent manner. These findings offer opportunities for the development of exosomes based biomarkers and therapies.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 15
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