Mechanobiology of the nucleus during the G2-M transition

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

Lima, JT (Author) Other; J Ferreira (Author) FMUP

Journal

Title: Nucleus

Vol. 15

ISSN: 1949-1034

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-010-9K7

DOI: 10.1080/19491034.2024.2330947

Abstract (EN): Cellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events. Therefore, the nucleus has emerged as a regulator of cellular response to mechanical stimuli. Cell cycle progression is regulated by cyclin-CDK complexes. Recent studies demonstrated these biochemical pathways are influenced by mechanical signals, highlighting the interdependence of cellular mechanics and cell cycle regulation. In particular, the transition from G2 to mitosis (G2-M) shows significant changes in nuclear structure and organization, ranging from nuclear pore complex (NPC) and nuclear lamina disassembly to chromosome condensation. The remodeling of these mechanically active nuclear components indicates that mitotic entry is particularly sensitive to forces. Here, we address how mechanical forces crosstalk with the nucleus to determine the timing and efficiency of the G2-M transition. Finally, we discuss how the deregulation of nuclear mechanics has consequences for mitosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16