Silver jubilee: 25 years of the first demonstration of the direct effect of phosphate on the parathyroid cell [Bodas de plata: 25 años de la primera demostracion del efecto directo del fósforo en la célula paratiroidea]

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Bover, J (Author) Other; Trinidad, P (Author) Other; Jara, A (Author) Other; Soler Majoral, J (Author) Other; Martín Malo, A (Author) Other; Torres, A (Author) Other; João Frazão (Author) FMUP; Ureña, P (Author) Other; Dusso, A (Author) Other; Arana, C (Author) Other; Graterol, F (Author) Other; Romero González, G (Author) Other; Troya, M (Author) Other; Samaniego, D (Author) Other; D'Marco, L (Author) Other; Valdivielso, JM (Author) Other; Fernández, E (Author) Other; Arenas, MD (Author) Other; Torregrosa, V (Author) Other; Navarro González, JF (Author) Other; Lloret, MJ (Author) Other; Ballarín, JA (Author) Other; Bosch, RJ (Author) Other; Górriz, JL (Author) Other; de Francisco, AGL (Author) Other; Gutiérrez, O (Author) Other; Ara, J (Author) Other; Felsenfeld, A (Author) Other; Canalejo, A (Author) Other; Almadén, Y (Author) Other

Journal

Title: Nefrología (English Edition)

Vol. 42

Pages: 645-655

ISSN: 2013-2514

Publisher: Sociedad Española de Nefrología

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-00Y-6QB

DOI: 10.1016/j.nefroe.2023.02.008

Abstract (EN): Although phosphorus is an essential element for life, it is not found in nature in its native state but rather combined in the form of inorganic phosphates (PO43¿), with tightly regulated plasma levels that are associated with deleterious effects and mortality when these are out of bounds. The growing interest in the accumulation of PO43¿ in human pathophysiology originated in its attributed role in the pathogenesis of secondary hyperparathyroidism (SHPT) in chronic kidney disease. In this article, we review the mechanisms by which this effect was justified and we commemorate the important contribution of a Spanish group led by Dr. M. Rodríguez, just 25 years ago, when they first demonstrated the direct effect of PO43¿ on the regulation of the synthesis and secretion of parathyroid hormone by maintaining the structural integrity of the parathyroid glands in their original experimental model. In addition to demonstrating the importance of arachidonic acid (AA) and the phospholipase A2-AA pathway as a mediator of parathyroid gland response, these findings were predecessors of the recent description of the important role of PO43- on the activity of the calcium sensor-receptor, and also fueled various lines of research on the importance of PO43¿ overload not only for the pathophysiology of SHPT but also in its systemic pathogenic role. © 2022 Sociedad Española de Nefrología

Language: English

Type (Professor's evaluation): Scientific