A cohort study of the relationship between anaemia, mean corpuscular volume and mortality among a CKD population in South Africa

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Nalado A. (Author) Other; Waziri B. (Author) Other; Olorunfemi G. (Author) Other; Mahlangu J. (Author) Other; Paget G. (Author) Other; Duarte R (Author) FMUP; Naicker S. (Author) Other

Journal

Title: African Health Sciences

Vol. 21

Pages: 1764-1775

ISSN: 1680-6905

Publisher: Makerere University

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-010-SW3

DOI: 10.4314/ahs.v21i4.33

Abstract (EN): Background: The burden of chronic kidney disease is increasing globally and prompt identification, coupled with improved management of CKD patients have increased the population of pre-dialysis patients. We, therefore, aimed to evaluate the predictors of survival among pre-dialysis CKD patients in South Africa. Methods: We conducted a cohort study of 256 consecutive consenting Black non-dialysis requiring CKD patients attending the renal outpatient clinic of a tertiary Hospital in South Africa from 1st June 2016 to 1st December 2016. Socio-demographic and clinical information of the participants were obtained. Descriptive statistics, Kaplan-Meier curves and Cox proportional hazard regression analyses were conducted to evaluate factors affecting the survival of the participants. Results: The mean age of the participants was 52.8±14.3 years and 48.0% were females, 52% were males. The death rate increased with worsening haemoglobin level from 0.96 among patients with mild anaemia to 4.29 per 100-person years among patients with severe anaemia. Anaemic patients with GFR < 30mls/min had significantly increased risk of death (HR 11.51, 95% CI 1.62¿78.32, P < 0.001). Conclusion: Mortality in pre-dialysis CKD patients was associated with anaemia and hyperphosphatemia. Clinical interventions targeted at preventing these conditions may improve outcomes among this group of CKD patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11