Surveillance of adverse events in the treatment of drug-resistant tuberculosis: A global feasibility study

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Akkerman, O (Author) Other; Aleksa, A (Author) Other; Alffenaar, JW (Author) Other; Al Marzouqi, NH (Author) Other; Arias Guillen, M (Author) Other; Belilovski, E (Author) Other; Bernal, E (Author) Other; Boeree, MJ (Author) Other; Borisov, SE (Author) Other; Bruchfeld, J (Author) Other; Cadinanos Loidi, JC (Author) Other; Cai, QS (Author) Other; Caminero, JA (Author) Other; Cebrian Gallardo, JJC (Author) Other; Centis, R (Author) Other; Codecasa, LR (Author) Other; D'Ambrosio, L (Author) Other; Dalcolmo, M (Author) Other; Danila, E (Author) Other; Dara, M (Author) Other; Davidaviciene, E (Author) Other; Forsman, LD (Author) Other; Rios Jefe, JDR (Author) Other; Denholm, J (Author) Other; Duarte R (Author) Other; Elamin, SE (Author) Other; Ferrarese, M (Author) Other; Filippov, A (Author) Other; Ganatra, S (Author) Other; Garcia, A (Author) Other; Garcia Garcia, JM (Author) Other; Gayoso, R (Author) Other; Giraldo Montoya, AMG (Author) Other; Gomez Rosso, RGG (Author) Other; Gualano, G (Author) Other; Hoefsloot, W (Author) Other; Ilievska Poposka, B (Author) Other; Jonsson, J (Author) Other; Khimova, E (Author) Other; Kuksa, L (Author) Other; Kunst, H (Author) Other; Laniado Laborin, R (Author) Other; Li, Y (Author) Other; Magis Escurra, C (Author) Other; Manfrin, V (Author) Other; Manga, S (Author) Other; Marchese, V (Author) Other; Martinez Robles, EM (Author) Other; Maryandyshev, A (Author) Other; Matteelli, A (Author) Other; Migliori, GB (Author) Other; Mullerpattan, JB (Author) Other; Munoz Torrico, M (Author) Other; Hamdan, HM (Author) Other; Nieto Marcos, MN (Author) Other; Noordin, NM (Author) Other; Juan Palmero, DJ (Author) Other; Palmieri, F (Author) Other; Payen, MC (Author) Other; Piubello, A (Author) Other; Pontali, E (Author) Other; Pontarelli, A (Author) Other; Quiros, S (Author) Other; Rendon, A (Author) Other; Skrahina, A (Author) Other; Smite, A (Author) Other; Solovic, I (Author) Other; Sotgiu, G (Author) Other; Souleymane, MB (Author) Other; Spanevello, A (Author) Other; Stosic, M (Author) Other; Tadolini, M (Author) Other; Tiberi, S (Author) Other; Udwadia, ZF (Author) Other; van den Boom, M (Author) Other; Vescovo, M (Author) Other; Viggiani, P (Author) Other; Visca, D (Author) Other; Zhurkin, D (Author) Other; Zignol, M (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Vol. 83

Pages: 72-76

ISSN: 1201-9712

Indexing

ISI Web of Knowledge - 34 Citations

Scopus - 42 Citations

Other information

Authenticus ID: P-00Q-JWA

DOI: 10.1016/j.ijid.2019.03.036

Abstract (EN): The World Health Organization launched a global initiative, known as aDSM (active TB drug safety monitoring and management) to better describe the safety profile of new treatment regimens for drug-resistant tuberculosis (TB) in real-world settings. However, comprehensive surveillance is difficult to implement in several countries. The aim of the aDSM project is to demonstrate the feasibility of implementing national aDSM registers and to describe the type and the frequency of adverse events (AEs) associated with exposure to the new anti-TB drugs. Following a pilot study carried out in 2016, official involvement of TB reference centres/countries into the project was sought and cases treated with bedaquiline- and/or delamanid-containing regimens were consecutively recruited. AEs were prospectively collected ensuring potential attribution of the AE to a specific drug based on its known safety profile. A total of 309 cases were fully reported from 41 centres in 27 countries (65% males; 268 treated with bedaquiline, 20 with delamanid, and 21 with both drugs) out of an estimated 781 cases the participating countries had committed to report by the first quarter of 2019. (C) 2019 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5