Multidrug-Resistant Tuberculosis in Europe, 2010-2011

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Gunther, G (Author) Other; Van Leth, F (Author) Other; Alexandru, S (Author) Other; Altet, N (Author) Other; Avsar, K (Author) Other; Bang, D (Author) Other; Barbuta, R (Author) Other; Bothamley, G (Author) Other; Ciobanu, A (Author) Other; Crudu, V (Author) Other; Danilovits, M (Author) Other; Dedicoat, M (Author) Other; Duarte R (Author) FMUP; Gualano, G (Author) Other; Kunst, H (Author) Other; De Lange, W (Author) Other; Leimane, V (Author) Other; Magis Escurra, C (Author) Other; McLaughlin, AM (Author) Other; Muylle, I (Author) Other; Polcova, V (Author) Other; Pontali, E (Author) Other; Popa, C (Author) Other; Rumetshofer, R (Author) Other; Skrahina, A (Author) Other; Solodovnikova, V (Author) Other; Spinu, V (Author) Other; Tiberi, S (Author) Other; Viiklepp, P (Author) Other; Lange, C (Author) Other; Rowhani, M (Author) Other; Avchinko, V (Author) Other; Katovich, D (Author) Other; Klimuk, D (Author) Other; Lobik, V (Author) Other; Rohaya, Z (Author) Other; Shirochyn, A (Author) Other; Kotrbova, J (Author) Other; Vasakova, M (Author) Other; Andersen, AB (Author) Other; Smitsman, N (Author) Other; Mutterlein, R (Author) Other; De Lorenzo, S (Author) Other; Rusmane, L (Author) Other; Donica, A (Author) Other; Cernenco, I (Author) Other; Dubceac, V (Author) Other; Cuppen, F (Author) Other; De Guchtenaire, I (Author) Other; Meesters, R (Author) Other; Te Pas, M (Author) Other; Prins, B (Author) Other; Atunes, A (Author) Other; Gainaru, D (Author) Other; Ibraim, E (Author) Other; Tigau, M (Author) Other; Cayla, J (Author) Other; Fina, L (Author) Other; De Souza Galvao, ML (Author) Other; Maldonado, J (Author) Other

Journal

Title: Emerging Infectious Diseases

Vol. 21

Pages: 409-416

ISSN: 1080-6040

Publisher: Centers for Disease Control and Prevention (CDC)

Indexing

ISI Web of Knowledge - 66 Citations

Scopus - 71 Citations

Other information

Authenticus ID: P-00A-6H5

DOI: 10.3201/eid2103.141343

Abstract (EN): Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to >= 1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fluoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8