Myocardial deformation analysis using cardiac magnetic resonance in apical hypertrophic cardiomyopathy: is it an useful tool to predict adverse outcomes?

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Fernandes, RM (Author) Other; Brandao, M (Author) Other; Ladeiras-Lopes R (Author) FMUP; Faria, R (Author) Other; Ferreira, ND (Author) Other; Fontes-Carvalho R (Author) FMUP

Journal

Title: International Journal of Cardiovascular Imaging

Vol. 39

Pages: 1997-2003

ISSN: 1569-5794

Publisher: Springer Nature

Indexing

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Other information

Authenticus ID: P-00Y-R0S

DOI: 10.1007/s10554-023-02902-1

Abstract (EN): Apical hypertrophic cardiomyopathy (AHCM) has a broad phenotypic spectrum and still poses many diagnostic and prognostic challenges. Our team performed a retrospective study to examine the prognostic value of myocardial deformation obtained with cardiac magnetic resonance tissue tracking (CMR-TT) analysis in predicting adverse events in AHCM patients. We included patients with AHCM referred to CMR in our department from August 2009 to October 2021. CMR-TT analysis was performed to characterize the myocardial deformation pattern. Clinical, other complementary diagnostic exams characteristics and follow-up data were analysed. Primary endpoint was the composite of all-cause hospitalizations and mortality. During the 12-year period, 51 AHCM patients were evaluated by CMR, with a median age of 64 years-old and male predominance. 56,9% had an echocardiogram suggestive of AHCM. The most frequent phenotype was the relative form (43,1%). CMR evaluation revealed a median maximum left ventricle thickness of 15 mm and the presence of late gadolinium enhancement in 78,4%. Applying CMR-TT analysis, median global longitudinal strain was - 14,4%, with a median global radial strain of 30,4% and global circumferential strain of -18,0%. During a median follow-up of 5,3 years, the primary endpoint occurred in 21,3% of patients, with a hospitalization rate of 17,8% and all-cause mortality rate of 6,4%. After multivariable analysis, longitudinal strain rate in apical segments was an independent predictor of the primary endpoint (p = 0,023), showing that CMR-TT analysis could be useful in predicting adverse events in AHCM patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7