Statistical simplex centroid experimental design for evaluation of pectin, modified chitosan and modified starch as encapsulating agents on the development of vitamin E-loaded microparticles by spray-drying

• Type: Article in International Scientific Journal
• Date: 2024

Authors

Ribeiro, AM (Author) Other; Goncalves, A (Author) Other; Rocha, F (Author) Other; Berta Nogueiro Estevinho (Author) FEUP

Journal

Title: International Journal of Biological Macromolecules

Vol. 269

ISSN: 0141-8130

Publisher: Elsevier

Indexing

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Other information

Authenticus ID: P-010-EAY

DOI: 10.1016/j.ijbiomac.2024.131792

Abstract (EN): Vitamin E encapsulation into biopolymer-based microparticles, obtained by spray-drying technology, was proposed to improve the encapsulation efficiency and the controlled release of fat-soluble vitamin. Binary and ternary blends of pectin, modified chitosan and modified starch, modified starch + modified chitosan, modified starch + pectin, modified chitosan + pectin and modified starch + modified chitosan + pectin ((0.33, 0.33, 0.33), (0.70, 0.15, 0.15), (0.15, 0.70, 0.15) and (0.15, 0.15, 0.70)) were proposed to produce and evaluate different carrier-based delivery systems. Vitamin E-loaded microparticles and empty microparticles were created with a product yield between 9 and 49 %. The mean diameter among all microparticles varied between 3.74 +/- 0.02 and 421 +/- 21 mu m (differential volume distribution). Oval, spherical or irregular microparticles, with a variable morphology from a smooth to a high rough surface structure, with concavities, were produced. All vitamin E-loaded microparticles exhibited an encapsulation efficiency higher than 70 %. The slower vitamin E controlled release was observed from microparticles composed by modified chitosan (>36 h), while the faster release was achieved from microparticles individually composed by pectin (39 min). In general, the Fickian diffusion is the main release mechanism involved in the microparticles produced with modified chitosan, other formulations combine also other mechanisms such as swelling.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12