Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

Rodrigues, L (Author) Other; Paula, AD (Author) Other; Soares, P (Author) FMUP; Vinagre, J (Author) Other

Journal

Title: Cells

Vol. 13

Final page: 561

ISSN: 2073-4409

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-010-AT5

DOI: 10.3390/cells13070561

Abstract (EN): MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting DGCR8, the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14