Adipose tissue rearrangement in cancer cachexia: The involvement of ß3-adrenergic receptor associated pathways

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

Mota, INR (Author) Other; Satari, S (Author) Other; Marques, IS (Author) Other; Santos, JMO (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Biochimica et Biophysica Acta - Reviews on Cancer

Vol. 1879

ISSN: 0304-419X

Publisher: Elsevier

Indexing

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Other information

Authenticus ID: P-010-D3K

DOI: 10.1016/j.bbcan.2024.189103

Abstract (EN): Cancer-associated cachexia (CAC) is a complex multiple organ syndrome that significantly contributes to reduced quality of life and increased mortality among many cancer patients. Its multifactorial nature makes its early diagnosis and effective therapeutic interventions challenging. Adipose tissue is particularly impacted by cachexia, typically through increased lipolysis, browning and thermogenesis, mainly at the onset of the disease. These processes lead to depletion of fat mass and contribute to the dysfunction of other organs. The beta-adrenergic signalling pathways are classical players in the regulation of adipose tissue metabolism. They are activated upon sympathetic stimulation inducing lipolysis, browning and thermogenesis, therefore contributing to energy expenditure. Despite accumulating evidence suggesting that beta 3-adrenergic receptor stimulation may be crucial to the adipose tissue remodelling during cachexia, the literature remains controversial. Moreover, there is limited knowledge regarding sexual dimorphism of adipose tissue in the context of cachexia. This review paper aims to present the current knowledge regarding adipose tissue wasting during CAC, with a specific focus on the role of the beta 3-adrenergic receptor, placing it as a potential therapeutic target against cachexia.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12