Disseminated Mycobacterium bovis Infection: A Rare Complication of Bacillus Calmette-Guérin Immunotherapy

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Mendes, MH (Author) Other; Guimaraes, A (Author) Other; Ferreira, CD (Author) Other; Carneiro F (Author) FMUP; santos, l (Author) FMUP

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00Z-R6D

DOI: 10.7759/cureus.50407

Abstract (EN): Intravesical instillation of bacillus Calmette-Guerin (BCG) is a crucial adjunctive therapy in the treatment of bladder carcinoma. Its systemic complications are rare but include disseminated Mycobacterium bovis (M. bovis) infections, the diagnosis of which is a challenging task that requires keen clinical awareness. We report the case of an adult male treated with BCG who presented with fever, nonspecific constitutional symptoms, hepatic cytolysis, and cholestasis. After a detailed workup, the diagnosis was made of disseminated M. bovis infection with hepatic, pulmonary, renal, and ureteral involvement. Prompt antituberculosis treatment resulted in clinical and analytical improvement. This case highlights the importance of early recognition of this serious complication in patients with BCG exposure, as well as the difficulty in confirming the diagnosis for proper treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4