Development and validation of predictive equations for spirometry in Portuguese children

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Martins C. (Author) Other; Severo M (Author) ICBAS; Silva D. (Author) FMUP; Barros H (Author) FMUP; Moreira, André (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Journal of Allergy and Clinical Immunology: Global

Vol. 2

ISSN: 2772-8293

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-00Z-H6W

DOI: 10.1016/j.jacig.2023.100084

Abstract (EN): Background: There are no data on lung function reference values for Portuguese children, and the contribution from the Portuguese data set in the Global Lung Function Initiative (GLI) is scant. Objectives: We aimed to estimate new up-to-date reference values for Portuguese children by fitting a multivariable regression model to a general population sample. Further, we intended to assess the external validity of the obtained reference values and to compare them to the GLI reference values. Methods: A random sample of 858 children from 20 primary schools were screened by health questionnaire, physical examination, and spirometry. Spirometric parameters recorded were FVC, FEV1, and FEF25-75. Multiple regression models were used to derive reference equations. Results: Overall, 481 children, aged between 7 and 12 years, 267 boys (55.5%), were included. Boys had higher values for FVC and FEV1 than girls (P <.05). The strongest correlation was found for FVC with height (r = 0.71 for boys and 0.70 for girls), while the lowest correlation was observed in both sexes for FEF25-75 with age (r = 0.23). Height was the most significant predictor of FVC, FEV1, and FEF25-75 in our models. Weight and body mass index were not significant predictors for boys but had a significant effect on girls¿ equations for all spirometry parameters. Compared to obtained reference equations with GLI, they performed better for FVC in boys, FEV1 in girls, and FEF25-75 in both boys and girls. Conclusion: We offer up-to-date reference values of spirometry for Portuguese children that can be used in clinical practice and research.

Language: English

Type (Professor's evaluation): Scientific