Graphene-based materials biocompatibility: A review

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Artur Pinto (Author) FEUP; Ines C Goncalves (Author) FEUP; Fernao D Magalhaes (Author) FEUP

Journal

Title: Colloids and Surfaces B: Biointerfaces

Vol. 111

Pages: 188-202

ISSN: 0927-7765

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 234 Citations

ISI Web of Science

Scopus - 342 Citations

Scientific classification

FOS: Engineering and technology > Materials engineering

CORDIS: Health sciences > Medical sciences ; Technological sciences > Engineering > Materials engineering

Associated Projects

UI0511 - PROJECTO ESTRATÉGICO - UI 511 - 2013-2014

Other information

Authenticus ID: P-006-6E8

DOI: 10.1016/j.colsurfb.2013.05.022

Abstract (EN): Graphene-based materials (GBMs) have broad potential applications in biomedical engineering and biotechnology. However, existing studies regarding biological effects of GBMs often present contradictory or inconclusive results. This work presents a review of published data in order to provide a critical overview of the state of the art. Firstly, the distinct physical-chemical nature of the GBMs available is clarified, as well as the production methods involved. The review then discusses the available in vitro (with bacterial and mammalian cells) and in vivo studies concerning evaluation of GBMs biocompatibility, as well as existing hemocompatibility studies. The biocompatibility issues concerning composite materials that incorporate GBMs are addressed in a separate section, since encapsulation in a polymer matrix modifies biological interactions. The most pertinent questions that should be addressed in future works are also emphasized.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15