Inflammatory granulocytes decrease subcutaneous growth of melanoma in mice

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Costa, MM (Author) ICBAS; AP Águas (Author) ICBAS

Journal

Title: Inflammation

Vol. 28

Pages: 355-357

ISSN: 0360-3997

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-000-7GB

DOI: 10.1007/s10753-004-6646-7

Abstract (EN): Growing melanomas invade the subcutaneous tissues. We have compared the size of tumors implanted in the subcutaneous cavities of C57BL/6 mice where inflammatory reactions were induced before the injection of 5x10(5) melanoma cells (B16F10 cell line). Granulocytic inflammation of the subcutaneous cavities resulted in a significant decrease in the growth of the implanted melanomas, whereas monocytic inflammation had no effect on tumor growth. We conclude that granulocytes, but not monocytes/macrophages, have anti-tumor action on melanoma that invade the subcutaneous tissues.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3