Reviving the interest in the versatile drug nystatin: A multitude of strategies to increase its potential as an effective and safe antifungal agent

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Sousa, F (Author) Other; Nascimento, C (Author) Other; Ferreira, D (Author) Other; Reis, S (Author) Other; Paulo Costa (Author) FFUP

Journal

Title: Advanced Drug Delivery Reviews

Vol. 199

ISSN: 0169-409X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-PW4

DOI: 10.1016/j.addr.2023.114969

Abstract (EN): Nystatin is an antifungal molecule with a remarkable yet squandered versatility. In this review, its mechanism of action is explored, along with its extensive action spectrum and toxicity. A multitude of methodologies to tackle the drug's physical and chemical hurdles are outlined along with some proven-effective strategies to increase its activity and/or decrease its toxicity.A separate detailed section focused on micro and nanotechnology solutions addresses new drug delivery systems made of polymeric, metallic or lipid materials. Although the topical route depicts greater representativeness amongst these formulations, the intravenous, dental, oral, vaginal and inhalation routes are also mentioned.The unsuccessful previous attempts at developing parenteral formulations of nystatin or even the withdrawal of a nystatin-loaded multilamellar liposome should not divert research away from this drug. In fact, the interest in nystatin ought to be reawakened with the ongoing clinical trials on the promising nystatin-like genetically engineered derivate BSG005.& COPY; 2023 The Author(s). Published by Elsevier B.V.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 35