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Reviving the interest in the versatile drug nystatin: A multitude of strategies to increase its potential as an effective and safe antifungal agent

Title
Reviving the interest in the versatile drug nystatin: A multitude of strategies to increase its potential as an effective and safe antifungal agent
Type
Another Publication in an International Scientific Journal
Year
2023
Authors
Sousa, F
(Author)
Other
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Nascimento, C
(Author)
Other
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Ferreira, D
(Author)
Other
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Reis, S
(Author)
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Paulo Costa
(Author)
FFUP
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Journal
Vol. 199
ISSN: 0169-409X
Publisher: Elsevier
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Publicação em ISI Web of Knowledge ISI Web of Knowledge - 0 Citations
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Other information
Authenticus ID: P-00Y-PW4
Abstract (EN): Nystatin is an antifungal molecule with a remarkable yet squandered versatility. In this review, its mechanism of action is explored, along with its extensive action spectrum and toxicity. A multitude of methodologies to tackle the drug's physical and chemical hurdles are outlined along with some proven-effective strategies to increase its activity and/or decrease its toxicity.A separate detailed section focused on micro and nanotechnology solutions addresses new drug delivery systems made of polymeric, metallic or lipid materials. Although the topical route depicts greater representativeness amongst these formulations, the intravenous, dental, oral, vaginal and inhalation routes are also mentioned.The unsuccessful previous attempts at developing parenteral formulations of nystatin or even the withdrawal of a nystatin-loaded multilamellar liposome should not divert research away from this drug. In fact, the interest in nystatin ought to be reawakened with the ongoing clinical trials on the promising nystatin-like genetically engineered derivate BSG005.& COPY; 2023 The Author(s). Published by Elsevier B.V.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 35
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