The Impact of Early-Stage Chronic Kidney Disease on Weight Loss Outcomes After Gastric Bypass

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Pereira, J (Author) Other; Pereira, PR (Author) Other; Andrade, S (Author) Other; Pereira, SS (Author) ICBAS; Nora, M (Author) Other; Guimaraes, M (Author) Other; Monteiro, M (Author) ICBAS

Journal

Title: Obesity Surgery

ISSN: 0960-8923

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Z-53S

DOI: 10.1007/s11695-023-06862-2

Abstract (EN): Purpose: Weight loss achieved through bariatric metabolic surgery was demonstrated to be effective at reversing chronic kidney dysfunction associated with obesity-related glomerulopathy. However, robust data on how pre-operative kidney status impacts on bariatric metabolic surgery weight loss outcomes is still lacking. The aim of this study was to evaluate the impact of kidney dysfunction on weight loss outcomes after bariatric metabolic surgery.Methods: Patients with obesity to be submitted to gastric bypass surgery underwent a pre-operative evaluation of creatinine clearance, estimated glomerular filtration rate (eGFR), proteinuria, and albuminuria in 24-hour urine. Body mass index (BMI), % total weight loss (%TWL), and % excess BMI loss (%EBMIL) were assessed at 6 and 12 months after surgery.Results: Before surgery, patients (N=127) had a mean BMI of 39.6 +/- 3.0 kg/m(2), and 56.7% (n=72) had a creatinine clearance > 130 mL/min, 23.6% (n= 30) presented proteinuria > 150 mg/24h, and 15.0% (n= 19) presented albuminuria > 30 mg/24h. After surgery, the mean BMI was 27.7 kg/m(2) and 25.0 kg/m(2) at 6 and 12 months, respectively (p<0.0001). The %TWL was lower in patients with pre-operative eGFR < percentile 25 (34.4 +/- 5.8% vs 39.4 +/- 4.9%, p=0.0007, at 12 months). There were no significant correlations between weight loss metrics and pre-operative creatinine clearance rate, proteinuria, or albuminuria.Conclusion: Early-stage chronic kidney disease (G2) has a negative impact on short-term weight loss outcomes after bariatric metabolic surgery, albeit in a magnitude inferior to the clinically relevant threshold.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11