Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Mereiter, S (Author) Other; Balmana, M (Author) Other; Campos, D (Author) Other; Gomes, J (Author) Other; Celso Reis (Author) ICBAS

Journal

Title: Cancer Cell

Vol. 36

Pages: 6-16

ISSN: 1535-6108

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 153 Citations

Scopus - 158 Citations

Other information

Authenticus ID: P-00Q-RDY

DOI: 10.1016/j.ccell.2019.06.006

Abstract (EN): This review provides insights on the impact of glycosylation in cancer biology and its influence in the current approaches of targeted cancer therapies in the clinical setting. The roles of glycosylation in cancer signaling, tumor progression, and metastasis are reviewed as well as glycans and glycan-binding proteins in tumor immunomodulation. Moreover, the latest reports on glycans influencing targeted therapeutic approaches in cancer are summarized. Finally, we discuss the future challenges of the field, outlining potential applications of glycan-based biomarkers for patient stratification and strategies for improving personalized cancer treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11