The singularity of Cetacea behaviour parallels the complete inactivation of melatonin gene modules

• Type: Other Publications
• Date: 2018

Authors

Lopes-Marques, M (Author) Other; Ruivo, R (Author) Other; Alves, LQ (Author) Other; Sousa, N (Author) Other; Machado, AM (Author) Other; Filipe F C Castro (Author) FCUP

Other information

Authenticus ID: P-00Y-DHG

DOI: 10.1101/490219

Abstract (EN): <jats:p>Melatonin, the hormone of darkness, is a peculiar molecule found in most living organisms. Emerging as a potent broad-spectrum antioxidant, melatonin was repurposed into extra roles such as the modulation of circadian and seasonal rhythmicity: affecting numerous aspects of physiology and behaviour, including sleep entrainment and locomotor activity. Interestingly, the pineal gland¿the melatonin synthesising organ in vertebrates¿was suggested to be absent or rudimentary in some mammalian lineages, including Cetacea. In Cetacea, pineal regression is paralleled by their unique bio-rhythmicity, as illustrated by the unihemispheric sleeping behaviour and long-term vigilance. Here, we examined the genes responsible for melatonin synthesis (Aanat and Asmt) and signalling (Mtnr1a and Mtnr1b) in 12 toothed and baleen whale genomes. Based on an ample genomic comparison, we deduce that melatonin-related gene modules are eroded in Cetacea.</jats:p>

Language: English

Type (Professor's evaluation): Scientific