The inflammasome in biomaterial-driven immunomodulation

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Vasconcelos, DP (Author) Other; Aguas, AP (Author) Other; Judite N Barbosa (Author) ICBAS

Journal

Title: Journal of tissue engineering and regenerative medicine

Vol. 16

Pages: 1109-1120

ISSN: 1932-6254

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00X-FK6

DOI: 10.1002/term.3361

Abstract (EN): Inflammasomes are intracellular structures formed upon the assembly of several proteins that have a considerable size and are very important in innate immune responses being key players in host defense. They are assembled after the perception of pathogens or danger signals. The activation of the inflammasome pathway induces the production of high levels of the pro-inflammatory cytokines Interleukin (IL)-1 beta and IL-18 through the caspase activation. The procedure for the implantation of a biomaterial causes tissue injury, and the injured cells will secrete danger signals recognized by the inflammasome. There is growing evidence that the inflammasome participates in a number of inflammatory processes, including pathogen clearance, chronic inflammation and tissue repair. Therefore, the control of the inflammasome activity is a promising target in the development of capable approaches to be applied in regenerative medicine. In this review, we revisit current knowledge of the inflammasome in the inflammatory response to biomaterials and point to the yet underexplored potential of the inflammasome in the context of immunomodulation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12