Characterization and management of the keratocystic odontogenic tumor in relation to its histopathological and biological features

• Type: Another Publication in an International Scientific Journal
• Date: 2010

Authors

Mendes, RA (Author) Other; Carvalho, JFC (Author) Other; van der Waal, I (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: ORAL ONCOLOGY

Vol. 46

Pages: 219-225

ISSN: 1368-8375

Indexing

ISI Web of Knowledge - 73 Citations

Scopus - 96 Citations

Other information

Authenticus ID: P-003-82P

DOI: 10.1016/j.oraloncology.2010.01.012

Abstract (EN): Keratocystic odontogenic tumor (KCOT), formerly referred to as odontogenic keratocyst, is a benign neoplasm of odontogenic origin which may present an aggressive and infiltrative behavior leading to high recurrence rates. A review of the various treatment modalities, ranging from simple enucleation to radical surgery is portrayed in relation to clinical, radiological, histopathological and molecular features. Although prognostic factors based on clinico-pathologic and immunohistochemical findings for determining the potential for recurrence of KCOT still remains unclear, its use for determining the potential for recurrence of KCOT after surgical treatment may become important to successfully manage this neoplasm's aggressive behavior. The key element for future management of KCOTs will probably be based on thorough knowledge of the biological basis of this tumor, thereby enabling a more tailored treatment approach.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7