Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis?

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Sonis, ST (Author) Other; Mendes, RA (Author) Other

Journal

Title: Journal of Oral Pathology & Medicine

Vol. 45

Pages: 469-474

ISSN: 0904-2512

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00T-FFE

DOI: 10.1111/jop.12436

Abstract (EN): The association between chronic inflammatory disorders and oral carcinogenesis has been both a source of interest and contention. Based upon its central importance in oral carcinogenesis, the finding that the PI3k/Akt/mTOR pathway is activated in oral lichen planus, chronic graftversus-host disease, and chronic oral candidiasis suggests that it may provide a link between benign and malignant oral conditions. Here, we discuss a possible mechanistic rationale that addresses the activation of this important signaling pathway and its downstream events, while correlating it with the carcinogenic potential of chronic oral disorders.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6