Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Almeida-Pinto, N (Author) Other; Dschietzig, TB (Author) Other; Brás-Silva C (Author) FMUP; Adao, R (Author) Other

Journal

Title: Clinical Research in Cardiology

ISSN: 1861-0684

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Scientific classification

CORDIS: Health sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00Z-2Y4

DOI: 10.1007/s00392-023-02305-1

Abstract (EN): The hormone relaxin-2 has emerged as a promising player in regulating the physiology of the cardiovascular system. Through binding to the relaxin family peptide receptor 1 (RXFP1), this hormone elicits multiple physiological responses including vasodilation induction, reduction of inflammation and oxidative stress, and angiogenesis stimulation. The role of relaxin-2, or its recombinant human form known as serelaxin, has been investigated in preclinical and clinical studies as a potential therapy for cardiovascular diseases, especially heart failure, whose current therapy is still unoptimized. However, evidence from past clinical trials has been inconsistent and further research is needed to fully understand the potential applications of relaxin-2. This review provides an overview of serelaxin use in clinical trials and discusses future directions in the development of relaxin-2 mimetics, which may offer new therapeutic options for patients with heart failure.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14