Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Conti, DV (Author) Other; Darst, BF (Author) Other; Moss, LC (Author) Other; Saunders, EJ (Author) Other; Sheng, X (Author) Other; Chou, A (Author) Other; Schumacher, FR (Author) Other; Al Olama, AA (Author) Other; Benlloch, S (Author) Other; Dadaev, T (Author) Other; Brook, MN (Author) Other; Sahimi, A (Author) Other; Hoffmann, TJ (Author) Other; Takahashi, A (Author) Other; Matsuda, K (Author) Other; Momozawa, Y (Author) Other; Fujita, M (Author) Other; Muir, K (Author) Other; Lophatananon, A (Author) Other; Wan, P (Author) Other; Le Marchand, L (Author) Other; Wilkens, LR (Author) Other; Stevens, VL (Author) Other; Gapstur, SM (Author) Other; Carter, BD (Author) Other; Schleutker, J (Author) Other; Tammela, TLJ (Author) Other; Sipeky, C (Author) Other; Auvinen, A (Author) Other; Giles, GG (Author) Other; Southey, MC (Author) Other; MacInnis, RJ (Author) Other; Cybulski, C (Author) Other; Wokolorczyk, D (Author) Other; Lubinski, J (Author) Other; Neal, DE (Author) Other; Donovan, JL (Author) Other; Hamdy, FC (Author) Other; Martin, RM (Author) Other; Nordestgaard, BG (Author) Other; Nielsen, SF (Author) Other; Weischer, M (Author) Other; Bojesen, SE (Author) Other; Roder, MA (Author) Other; Iversen, P (Author) Other; Batra, J (Author) Other; Chambers, S (Author) Other; Moya, L (Author) Other; Horvath, L (Author) Other; Clements, JA (Author) Other; Tilley, W (Author) Other; Risbridger, GP (Author) Other; Gronberg, H (Author) Other; Aly, M (Author) Other; Szulkin, R (Author) Other; Eklund, M (Author) Other; Nordstrom, T (Author) Other; Pashayan, N (Author) Other; Dunning, AM (Author) Other; Ghoussaini, M (Author) Other; Travis, RC (Author) Other; Key, TJ (Author) Other; Riboli, E (Author) Other; Park, JY (Author) Other; Sellers, TA (Author) Other; Lin, HY (Author) Other; Albanes, D (Author) Other; Weinstein, SJ (Author) Other; Mucci, LA (Author) Other; Giovannucci, E (Author) Other; Lindstrom, S (Author) Other; Kraft, P (Author) Other; Hunter, DJ (Author) Other; Penney, KL (Author) Other; Turman, C (Author) Other; Tangen, CM (Author) Other; Goodman, PJ (Author) Other; Thompson, IM (Author) Other; Hamilton, RJ (Author) Other; Fleshner, NE (Author) Other; Finelli, A (Author) Other; Parent, ME (Author) Other; Stanford, JL (Author) Other; Ostrander, EA (Author) Other; Geybels, MS (Author) Other; Koutros, S (Author) Other; Freeman, LEB (Author) Other; Stampfer, M (Author) Other; Wolk, A (Author) Other; Hakansson, N (Author) Other; Andriole, GL (Author) Other; Hoover, RN (Author) Other; Machiela, MJ (Author) Other; Sorensen, KD (Author) Other; Borre, M (Author) Other; Blot, WJ (Author) Other; Zheng, W (Author) Other; Yeboah, ED (Author) Other; Mensah, JE (Author) Other; Lu, YJ (Author) Other; Zhang, HW (Author) Other; Feng, NH (Author) Other; Mao, XY (Author) Other; Wu, YD (Author) Other; Zhao, SC (Author) Other; Sun, Z (Author) Other; Thibodeau, SN (Author) Other; McDonnell, SK (Author) Other; Schaid, DJ (Author) Other; West, CML (Author) Other; Burnet, N (Author) Other; Barnett, G (Author) Other; Maier, C (Author) Other; Schnoeller, T (Author) Other; Luedeke, M (Author) Other; Kibel, AS (Author) Other; Drake, BF (Author) Other; Cussenot, O (Author) Other; Cancel Tassin, G (Author) Other; Menegaux, F (Author) Other; Truong, T (Author) Other; Koudou, YA (Author) Other; John, EM (Author) Other; Grindedal, EM (Author) Other; Maehle, L (Author) Other; Khaw, KT (Author) Other; Ingles, SA (Author) Other; Stern, MC (Author) Other; Vega, A (Author) Other; Gomez Caamano, A (Author) Other; Fachal, L (Author) Other; Rosenstein, BS (Author) Other; Kerns, SL (Author) Other; Ostrer, H (Author) Other; Manuel R Teixeira (Author) ICBAS; Paulo, P (Author) Other; Brandao, A (Author) Other; Watya, S (Author) Other; Lubwama, A (Author) Other; Bensen, JT (Author) Other; Fontham, ETH (Author) Other; Mohler, J (Author) Other; Taylor, JA (Author) Other; Kogevinas, M (Author) Other; Llorca, J (Author) Other; Castano Vinyals, G (Author) Other; Cannon Albright, L (Author) Other; Teerlink, CC (Author) Other; Huff, CD (Author) Other; Strom, SS (Author) Other; Multigner, L (Author) Other; Blanchet, P (Author) Other; Brureau, L (Author) Other; Kaneva, R (Author) Other; Slavov, C (Author) Other; Mitev, V (Author) Other; Leach, RJ (Author) Other; Weaver, B (Author) Other; Brenner, H (Author) Other; Cuk, K (Author) Other; Holleczek, B (Author) Other; Saum, KU (Author) Other; Klein, EA (Author) Other; Hsing, AW (Author) Other; Kittles, RA (Author) Other; Murphy, AB (Author) Other; Logothetis, CJ (Author) Other; Kim, J (Author) Other; Neuhausen, SL (Author) Other; Steele, L (Author) Other; Ding, YC (Author) Other; Isaacs, WB (Author) Other; Nemesure, B (Author) Other; Hennis, AJM (Author) Other; Carpten, J (Author) Other; Pandha, H (Author) Other; Michael, A (Author) Other; De Ruyck, K (Author) Other; De Meerleer, G (Author) Other; Ost, P (Author) Other; Xu, JF (Author) Other; Razack, A (Author) Other; Lim, J (Author) Other; Teo, SH (Author) Other; Newcomb, LF (Author) Other; Lin, DW (Author) Other; Fowke, JH (Author) Other; Neslund Dudas, C (Author) Other; Rybicki, BA (Author) Other; Gamulin, M (Author) Other; Lessel, D (Author) Other; Kulis, T (Author) Other; Usmani, N (Author) Other; Singhal, S (Author) Other; Parliament, M (Author) Other; Claessens, F (Author) Other; Joniau, S (Author) Other; Van den Broeck, T (Author) Other; Gago Dominguez, M (Author) Other; Castelao, JE (Author) Other; Martinez, ME (Author) Other; Larkin, S (Author) Other; Townsend, PA (Author) Other; Aukim Hastie, C (Author) Other; Bush, WS (Author) Other; Aldrich, MC (Author) Other; Crawford, DC (Author) Other; Srivastava, S (Author) Other; Cullen, JC (Author) Other; Petrovics, G (Author) Other; Casey, G (Author) Other; Roobol, MJ (Author) Other; Jenster, G (Author) Other; van Schaik, RHN (Author) Other; Hu, JJ (Author) Other; Sanderson, M (Author) Other; Varma, R (Author) Other; McKean Cowdin, R (Author) Other; Torres, M (Author) Other; Mancuso, N (Author) Other; Berndt, SI (Author) Other; Van den Eeden, SK (Author) Other; Easton, DF (Author) Other; Chanock, SJ (Author) Other; Cook, MB (Author) Other; Wiklund, F (Author) Other; Nakagawa, H (Author) Other; Witte, JS (Author) Other; Eeles, RA (Author) Other; Kote Jarai, Z (Author) Other; Haiman, CA (Author) Other

Journal

Title: Nature Genetics

Vol. 53

Pages: 65-75

ISSN: 1061-4036

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 71 Citations

Scopus - 69 Citations

Other information

Authenticus ID: P-00T-9GH

DOI: 10.1038/s41588-020-00748-0

Abstract (EN): Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 30