Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Patel, VL (Author) Other; Busch, EL (Author) Other; Friebel, TM (Author) Other; Cronin, A (Author) Other; Leslie, G (Author) Other; McGuffog, L (Author) Other; Adlard, J (Author) Other; Agata, S (Author) Other; Agnarsson, BA (Author) Other; Ahmed, M (Author) Other; Aittomaki, K (Author) Other; Alducci, E (Author) Other; Andrulis, IL (Author) Other; Arason, A (Author) Other; Arnold, N (Author) Other; Artioli, G (Author) Other; Arver, B (Author) Other; Auber, B (Author) Other; Azzollini, J (Author) Other; Balmana, J (Author) Other; Barkardottir, RB (Author) Other; Barnes, DR (Author) Other; Barroso, A (Author) Other; Barrowdale, D (Author) Other; Belotti, M (Author) Other; Benitez, J (Author) Other; Bertelsen, B (Author) Other; Blok, MJ (Author) Other; Bodrogi, I (Author) Other; Bonadona, V (Author) Other; Bonanni, B (Author) Other; Bondavalli, D (Author) Other; Boonen, SE (Author) Other; Borde, J (Author) Other; Borg, A (Author) Other; Bradbury, AR (Author) Other; Brady, A (Author) Other; Brewer, C (Author) Other; Brunet, J (Author) Other; Buecher, B (Author) Other; Buys, SS (Author) Other; Cabezas Camarero, S (Author) Other; Caldes, T (Author) Other; Caliebe, A (Author) Other; Caligo, MA (Author) Other; Calvello, M (Author) Other; Campbell, IG (Author) Other; Carnevali, I (Author) Other; Carrasco, E (Author) Other; Chan, TL (Author) Other; Chu, ATW (Author) Other; Chung, WK (Author) Other; Claes, KBM (Author) Other; Cook, J (Author) Other; Cortesi, L (Author) Other; Couch, FJ (Author) Other; Daly, MB (Author) Other; Damante, G (Author) Other; Darder, E (Author) Other; Davidson, R (Author) Other; de la Hoya, M (Author) Other; Della Puppa, L (Author) Other; Dennis, J (Author) Other; Diez, O (Author) Other; Ding, YC (Author) Other; Ditsch, N (Author) Other; Domchek, SM (Author) Other; Donaldson, A (Author) Other; Dworniczak, B (Author) Other; Easton, DF (Author) Other; Eccles, DM (Author) Other; Eeles, RA (Author) Other; Ehrencrona, H (Author) Other; Ejlertsen, B (Author) Other; Engel, C (Author) Other; Evans, DG (Author) Other; Faivre, L (Author) Other; Faust, U (Author) Other; Feliubadalo, L (Author) Other; Foretova, L (Author) Other; Fostira, F (Author) Other; Fountzilas, G (Author) Other; Frost, D (Author) Other; Garcia Barberan, V (Author) Other; Garre, P (Author) Other; Gauthier Villars, M (Author) Other; Geczi, L (Author) Other; Gehrig, A (Author) Other; Gerdes, AM (Author) Other; Gesta, P (Author) Other; Giannini, G (Author) Other; Glendon, G (Author) Other; Godwin, AK (Author) Other; Goldgar, DE (Author) Other; Greene, MH (Author) Other; Gutierrez Barrera, AM (Author) Other; Hahnen, E (Author) Other; Hamann, U (Author) Other; Hauke, J (Author) Other; Herold, N (Author) Other; Hogervorst, FBL (Author) Other; Honisch, E (Author) Other; Hopper, JL (Author) Other; Hulick, PJ (Author) Other; Izatt, L (Author) Other; Jager, A (Author) Other; James, P (Author) Other; Janavicius, R (Author) Other; Jensen, UB (Author) Other; Jensen, TD (Author) Other; Johannsson, OT (Author) Other; John, EM (Author) Other; Joseph, V (Author) Other; Kang, E (Author) Other; Kast, K (Author) Other; Kiiski, JI (Author) Other; Kim, SW (Author) Other; Kim, Z (Author) Other; Ko, KP (Author) Other; Konstantopoulou, I (Author) Other; Kramer, G (Author) Other; Krogh, L (Author) Other; Kruse, TA (Author) Other; Kwong, A (Author) Other; Larsen, M (Author) Other; Lasset, C (Author) Other; Lautrup, C (Author) Other; Lazaro, C (Author) Other; Lee, J (Author) Other; Lee, JW (Author) Other; Lee, MH (Author) Other; Lemke, J (Author) Other; Lesueur, F (Author) Other; Liljegren, A (Author) Other; Lindblom, A (Author) Other; Llovet, P (Author) Other; Lopez Fernandez, A (Author) Other; Lopez Perolio, I (Author) Other; Lorca, V (Author) Other; Loud, JT (Author) Other; Ma, ESK (Author) Other; Mai, PL (Author) Other; Manoukian, S (Author) Other; Mari, V (Author) Other; Martin, L (Author) Other; Matricardi, L (Author) Other; Mebirouk, N (Author) Other; Medici, V (Author) Other; Meijers Heijboer, HEJ (Author) Other; Meindl, A (Author) Other; Mensenkamp, AR (Author) Other; Miller, C (Author) Other; Gomes, DM (Author) Other; Montagna, M (Author) Other; Mooij, TM (Author) Other; Moserle, L (Author) Other; Mouret Fourme, E (Author) Other; Mulligan, AM (Author) Other; Nathanson, KL (Author) Other; Navratilova, M (Author) Other; Nevanlinna, H (Author) Other; Niederacher, D (Author) Other; Nielsen, FCC (Author) Other; Nikitina Zake, L (Author) Other; Offit, K (Author) Other; Olah, E (Author) Other; Olopade, OI (Author) Other; Ong, KR (Author) Other; Osorio, A (Author) Other; Ott, CE (Author) Other; Palli, D (Author) Other; Park, SK (Author) Other; Parsons, MT (Author) Other; Pedersen, IS (Author) Other; Peissel, B (Author) Other; Peixoto, A (Author) Other; Perez Segura, P (Author) Other; Peterlongo, P (Author) Other; Petersen, AH (Author) Other; Porteous, ME (Author) Other; Angel Pujana, MA (Author) Other; Radice, P (Author) Other; Ramser, J (Author) Other; Rantala, J (Author) Other; Rashid, MU (Author) Other; Rhiem, K (Author) Other; Rizzolo, P (Author) Other; Robson, ME (Author) Other; Rookus, MA (Author) Other; Rossing, CM (Author) Other; Ruddy, KJ (Author) Other; Santos, C (Author) Other; Saule, C (Author) Other; Scarpitta, R (Author) Other; Schmutzler, RK (Author) Other; Schuster, H (Author) Other; Senter, L (Author) Other; Seynaeve, CM (Author) Other; Shah, PD (Author) Other; Sharma, P (Author) Other; Shin, VY (Author) Other; Silvestri, V (Author) Other; Simard, J (Author) Other; Singer, CF (Author) Other; Skytte, AB (Author) Other; Snape, K (Author) Other; Solano, AR (Author) Other; Soucy, P (Author) Other; Southey, MC (Author) Other; Spurdle, AB (Author) Other; Steele, L (Author) Other; Steinemann, D (Author) Other; Stoppa Lyonnet, D (Author) Other; Stradella, A (Author) Other; Sunde, L (Author) Other; Sutter, C (Author) Other; Tan, YY (Author) Other; Manuel R Teixeira (Author) ICBAS; Teo, SH (Author) Other; Thomassen, M (Author) Other; Tibiletti, MG (Author) Other; Tischkowitz, M (Author) Other; Tognazzo, S (Author) Other; Toland, AE (Author) Other; Tommasi, S (Author) Other; Torres, D (Author) Other; Toss, A (Author) Other; Trainer, AH (Author) Other; Tung, N (Author) Other; van Asperen, CJ (Author) Other; van der Baan, FH (Author) Other; van der Kolk, LE (Author) Other; van der Luijt, RB (Author) Other; van Hest, LP (Author) Other; Varesco, L (Author) Other; Varon Mateeva, R (Author) Other; Viel, A (Author) Other; Vierstrate, J (Author) Other; Villa, R (Author) Other; von Wachenfeldt, A (Author) Other; Wagner, P (Author) Other; Wang Gohrke, S (Author) Other; Wappenschmidt, B (Author) Other; Weitzel, JN (Author) Other; Wieme, G (Author) Other; Yadav, S (Author) Other; Yannoukakos, D (Author) Other; Yoon, SY (Author) Other; Zanzottera, C (Author) Other; Zorn, KK (Author) Other; D'Amico, AV (Author) Other; Freedman, ML (Author) Other; Pomerantz, MM (Author) Other; Chenevix Trench, G (Author) Other; Antoniou, AC (Author) Other; Neuhausen, SL (Author) Other; Ottini, L (Author) Other; Nielsen, HR (Author) Other; Rebbeck, TR (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: CANCER RESEARCH

Vol. 80

Pages: 624-638

ISSN: 0008-5472

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 24 Citations

Other information

Authenticus ID: P-00R-PK2

DOI: 10.1158/0008-5472.can-19-1840

Abstract (EN): Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. Weevaluated whether PSVs inBRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 30 region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. Significance: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15