Genome-Wide Association Study of Prostate Cancer-Specific Survival

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Szulkin, R (Author) Other; Karlsson, R (Author) Other; Whitington, T (Author) Other; Aly, M (Author) Other; Gronberg, H (Author) Other; Eeles, RA (Author) Other; Easton, DF (Author) Other; Kote Jarai, Z (Author) Other; Al Olama, AA (Author) Other; Benlloch, S (Author) Other; Muir, K (Author) Other; Giles, GG (Author) Other; Southey, MC (Author) Other; FitzGerald, LM (Author) Other; Henderson, BE (Author) Other; Schumacher, FR (Author) Other; Haiman, CA (Author) Other; Sipeky, C (Author) Other; Tammela, TLJ (Author) Other; Nordestgaard, BG (Author) Other; Key, TJ (Author) Other; Travis, RC (Author) Other; Neal, DE (Author) Other; Donovan, JL (Author) Other; Hamdy, FC (Author) Other; Pharoah, PDP (Author) Other; Pashayan, N (Author) Other; Khaw, KT (Author) Other; Stanford, JL (Author) Other; Thibodeau, SN (Author) Other; McDonnell, SK (Author) Other; Schaid, DJ (Author) Other; Maier, C (Author) Other; Vogel, W (Author) Other; Luedeke, M (Author) Other; Herkommer, K (Author) Other; Kibel, AS (Author) Other; Cybulski, C (Author) Other; Lubinski, J (Author) Other; Kluzniak, W (Author) Other; Cannon Albright, L (Author) Other; Brenner, H (Author) Other; Herrmann, V (Author) Other; Holleczek, B (Author) Other; Park, JY (Author) Other; Sellers, TA (Author) Other; Lim, HY (Author) Other; Slavov, C (Author) Other; Kaneva, RP (Author) Other; Mitev, VI (Author) Other; Spurdle, A (Author) Other; Manuel R Teixeira (Author) ICBAS; Paulo, P (Author) Other; Maia, S (Author) Other; Pandha, H (Author) Other; Michael, A (Author) Other; Kierzek, A (Author) Other; Batra, J (Author) Other; Clements, JA (Author) Other; Albanes, D (Author) Other; Andriole, GL (Author) Other; Berndt, SI (Author) Other; Chanock, S (Author) Other; Gapstur, SM (Author) Other; Giovannucci, EL (Author) Other; Hunter, DJ (Author) Other; Kraft, P (Author) Other; Le Marchand, L (Author) Other; Ma, J (Author) Other; Mondul, AM (Author) Other; Penney, KL (Author) Other; Stampfer, MJ (Author) Other; Stevens, VL (Author) Other; Weinstein, SJ (Author) Other; Trichopoulou, A (Author) Other; Bueno de Mesquita, BH (Author) Other; Tjonneland, A (Author) Other; Cox, DG (Author) Other; Maehle, L (Author) Other; Schleutker, J (Author) Other; Lindstroem, S (Author) Other; Wiklund, F (Author) Other

Journal

Title: Cancer Epidemiology Biomarkers and Prevention

Vol. 24

Pages: 1796-1800

ISSN: 1055-9965

Publisher: American Association for Cancer Research

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 25 Citations

Other information

Authenticus ID: P-00G-WCK

DOI: 10.1158/1055-9965.epi-15-0543

Abstract (EN): Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. (C) 2015 AACR.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5