Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Peterlongo, P (Author) Other; Chang Claude, J (Author) Other; Moysich, KB (Author) Other; Rudolph, A (Author) Other; Schmutzler, RK (Author) Other; Simard, J (Author) Other; Soucy, P (Author) Other; Eeles, RA (Author) Other; Easton, DF (Author) Other; Hamann, U (Author) Other; Wilkening, S (Author) Other; Chen, BW (Author) Other; Rookus, MA (Author) Other; Schmidt, M (Author) Other; van der Baan, FH (Author) Other; Spurdle, AB (Author) Other; Walker, LC (Author) Other; Lose, F (Author) Other; Maia, AT (Author) Other; Montagna, M (Author) Other; Matricardi, L (Author) Other; Lubinski, J (Author) Other; Jakubowska, A (Author) Other; Garcia, EBG (Author) Other; Olopade, OI (Author) Other; Nussbaum, RL (Author) Other; Nathanson, KL (Author) Other; Domchek, SM (Author) Other; Rebbeck, TR (Author) Other; Arun, BK (Author) Other; Karlan, BY (Author) Other; Orsulic, S (Author) Other; Lester, J (Author) Other; Chung, WK (Author) Other; Miron, A (Author) Other; Southey, MC (Author) Other; Goldgar, DE (Author) Other; Buys, SS (Author) Other; Janavicius, R (Author) Other; Dorfling, CM (Author) Other; van Rensburg, EJ (Author) Other; Ding, YC (Author) Other; Neuhausen, SL (Author) Other; Hansen, TVO (Author) Other; Gerdes, AM (Author) Other; Ejlertsen, B (Author) Other; Jonson, L (Author) Other; Osorio, A (Author) Other; Martinez Bouzas, C (Author) Other; Benitez, J (Author) Other; Conway, EE (Author) Other; Blazer, KR (Author) Other; Weitzel, JN (Author) Other; Manoukian, S (Author) Other; Peissel, B (Author) Other; Zaffaroni, D (Author) Other; Scuvera, G (Author) Other; Barile, M (Author) Other; Ficarazzi, F (Author) Other; Mariette, F (Author) Other; Fortuzzi, S (Author) Other; Viel, A (Author) Other; Giannini, G (Author) Other; Papi, L (Author) Other; Martayan, A (Author) Other; Tibiletti, MG (Author) Other; Radice, P (Author) Other; Vratimos, A (Author) Other; Fostira, F (Author) Other; Garber, JE (Author) Other; Donaldson, A (Author) Other; Brewer, C (Author) Other; Foo, C (Author) Other; Evans, DGR (Author) Other; Frost, D (Author) Other; Eccles, D (Author) Other; Brady, A (Author) Other; Cook, J (Author) Other; Tischkowitz, M (Author) Other; Adlard, J (Author) Other; Barwell, J (Author) Other; Walker, L (Author) Other; Izatt, L (Author) Other; Side, LE (Author) Other; Kennedy, MJ (Author) Other; Rogers, MT (Author) Other; Porteous, ME (Author) Other; Morrison, PJ (Author) Other; Platte, R (Author) Other; Davidson, R (Author) Other; Hodgson, SV (Author) Other; Ellis, S (Author) Other; Cole, T (Author) Other; Godwin, AK (Author) Other; Claes, K (Author) Other; Van Maerken, T (Author) Other; Meindl, A (Author) Other; Gehrig, A (Author) Other; Sutter, C (Author) Other; Engel, C (Author) Other; Niederacher, D (Author) Other; Steinemann, D (Author) Other; Plendl, H (Author) Other; Kast, K (Author) Other; Rhiem, K (Author) Other; Ditsch, N (Author) Other; Arnold, N (Author) Other; Varon Mateeva, R (Author) Other; Wappenschmidt, B (Author) Other; Wang Gohrke, S (Author) Other; Bressac de Paillerets, B (Author) Other; Buecher, B (Author) Other; Delnatte, C (Author) Other; Houdayer, C (Author) Other; Stoppa Lyonnet, D (Author) Other; Damiola, F (Author) Other; Coupier, I (Author) Other; Barjhoux, L (Author) Other; Venat Bouvet, L (Author) Other; Golmard, L (Author) Other; Boutry Kryza, N (Author) Other; Sinilnikova, OM (Author) Other; Caron, O (Author) Other; Pujol, P (Author) Other; Mazoyer, S (Author) Other; Belotti, M (Author) Other; Piedmonte, M (Author) Other; Friedlander, ML (Author) Other; Rodriguez, GC (Author) Other; Copeland, LJ (Author) Other; de la Hoya, M (Author) Other; Perez Segura, PP (Author) Other; Nevanlinna, H (Author) Other; Aittomaeki, K (Author) Other; van Os, TAM (Author) Other; Meijers Heijboer, HEJ (Author) Other; van der Hout, AH (Author) Other; Vreeswijk, MPG (Author) Other; Hoogerbrugge, N (Author) Other; Ausems, MGEM (Author) Other; van Doorn, HC (Author) Other; Collee, JM (Author) Other; Olah, E (Author) Other; Diez, O (Author) Other; Blanco, I (Author) Other; Lazaro, C (Author) Other; Brunet, J (Author) Other; Feliubadalo, L (Author) Other; Cybulski, C (Author) Other; Gronwald, J (Author) Other; Durda, K (Author) Other; Jaworska Bieniek, K (Author) Other; Sukiennicki, G (Author) Other; Arason, A (Author) Other; Chiquette, J (Author) Other; Manuel R Teixeira (Author) ICBAS; Olswold, C (Author) Other; Couch, FJ (Author) Other; Lindor, NM (Author) Other; Wang, XS (Author) Other; Szabo, CI (Author) Other; Offit, K (Author) Other; Corines, M (Author) Other; Jacobs, L (Author) Other; Robson, ME (Author) Other; Zhang, LY (Author) Other; Joseph, V (Author) Other; Berger, A (Author) Other; Singer, CF (Author) Other; Rappaport, C (Author) Other; Kaulich, DG (Author) Other; Pfeiler, G (Author) Other; Tea, MKM (Author) Other; Phelan, CM (Author) Other; Greene, MH (Author) Other; Mai, PL (Author) Other; Rennert, G (Author) Other; Mulligan, AM (Author) Other; Glendon, G (Author) Other; Tchatchou, S (Author) Other; Andrulis, IL (Author) Other; Toland, AE (Author) Other; Bojesen, A (Author) Other; Pedersen, IS (Author) Other; Thomassen, M (Author) Other; Jensen, UB (Author) Other; Laitman, Y (Author) Other; Rantala, J (Author) Other; von Wachenfeldt, A (Author) Other; Ehrencrona, H (Author) Other; Askmalm, MS (Author) Other; Borg, A (Author) Other; Kuchenbaecker, KB (Author) Other; McGuffog, L (Author) Other; Barrowdale, D (Author) Other; Healey, S (Author) Other; Lee, A (Author) Other; Pharoah, PDP (Author) Other; Chenevix Trench, G (Author) Other; Antoniou, AC (Author) Other; Friedman, E (Author) Other

Journal

Title: Cancer Epidemiology Biomarkers and Prevention

Vol. 24

Pages: 308-316

ISSN: 1055-9965

Publisher: American Association for Cancer Research

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 18 Citations

Other information

Authenticus ID: P-00A-5KY

DOI: 10.1158/1055-9965.epi-14-0532

Abstract (EN): Background: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes. Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach. Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments. Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies. (C)2014 AACR.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9