CHROMOSOME-ABNORMALITIES IN BENIGN HYPERPROLIFERATIVE DISORDERS OF EPITHELIAL AND STROMAL BREAST-TISSUE

• Type: Article in International Scientific Journal
• Date: 1995

Authors

DIETRICH, CU (Author) Other; PANDIS, N (Author) Other; Manuel R Teixeira (Author) Other; BARDI, G (Author) Other; GERDES, AM (Author) Other; ANDERSEN, JA (Author) Other; HEIM, S (Author) Other

Journal

Title: International Journal of Cancer

Vol. 60

Pages: 49-53

ISSN: 0020-7136

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 82 Citations

Scopus - 83 Citations

Other information

Authenticus ID: P-008-QA9

DOI: 10.1002/ijc.2910600107

Abstract (EN): Cytogenetic analysis of short-term cultures from 15 cases of benign proliferative breast disease (PBD), 1O diffuse PBD and 5 papillomas, and 15 fibroadenomas of the breast revealed clonal chromosome abnormalities in 7 diffuse PBD lesions, 4 papillomas and 5 fibroadenomas. The remaining 14 cases had a normal female chromosome complement. Cytogenetically unrelated abnormal clones were seen in 4 fibroadenomas and 2 PBDs. A single abnormal clone was found in 9 PBDs and 1 fibroadenoma. Three clonal abnormalities were seen as recurrent changes in 6 cases, namely interstitial deletions of 3p with 3p12-14 as the minimally common deleted segment (in 1 papilloma, 1 diffuse PBD with atypia and 1 mixed-pattern lesion with both papilloma and atypical diffuse PBD features), r(9)(p24q34) (in 1 diffuse PBD and 1 fibroadenoma), and del(1)(q12) (again in 1 diffuse PBD and 1 fibroadenoma). Intriguingly, 6 of the 16 abnormal cases had chromosome changes that have been seen repeatedly as primary abnormalities in breast carcinomas: der(16)t(1;16)(q10;p10), del(3)(p12p14), and del(1)(q12). We conclude that some of the chromosome anomalies frequently found in breast carcinomas are also present in PBD and fibroadenomas. These aberrations may be accepted as early, neoplasia-relevant mutations. However, they do not seem to be sufficient by themselves to unleash a malignant process. (C) 1995 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5