Cytogenetic comparison of primary tumors and lymph node metastases in breast cancer patients

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Pandis, N (Author) Other; Manuel R Teixeira (Author) Other; Adeyinka, A (Author) Other; Rizou, H (Author) Other; Bardi, G (Author) Other; Mertens, F (Author) Other; Andersen, JA (Author) Other; Bondeson, L (Author) Other; Sfikas, K (Author) Other; Qvist, H (Author) Other; Apostolikas, N (Author) Other; Mitelman, F (Author) Other; Heim, S (Author) Other

Journal

Title: Genes Chromosomes and Cancer

Vol. 22

Pages: 122-129

ISSN: 1045-2257

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 49 Citations

Scopus - 49 Citations

Other information

Authenticus ID: P-008-QA0

DOI: 10.1002/(sici)1098-2264(199806)22:2<122::aid-gcc6>3.0.co;2-z

Abstract (EN): Chromosome banding analysis of primary tumors and axillary lymph node metastases from IO breast cancer patients revealed abnormal karyotypes in all samples with cytogenetic similarities between the primary tumor and the metastasis in all informative pairs. Although karyotypically unrelated clones were also bound in the lymph node samples, they were less numerous than in the primary tumors, indicating that there was more genetic heterogeneity among the neoplastic cells in the primary than in the secondary tumors. On the other hand, some of the clones had become more complex in the metastases as a result of clonal evolution, and by and large these metastatic breast cancer cases had more karyotypic anomalies than do unselected primary breast carcinomas. Among the aberrations occurring more frequently, and that consequently may predispose to disease spread, were losses of chromosomes 17 and 22 and homogeneously staining regions, a cytogenetic sign of gene amplification. (C) 1998 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8