Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Eeles, RA (Author) Other; Al Olama, AA (Author) Other; Benlloch, S (Author) Other; Saunders, EJ (Author) Other; Leongamornlert, DA (Author) Other; Tymrakiewicz, M (Author) Other; Ghoussaini, M (Author) Other; Luccarini, C (Author) Other; Dennis, J (Author) Other; Jugurnauth Little, S (Author) Other; Dadaev, T (Author) Other; Neal, DE (Author) Other; Hamdy, FC (Author) Other; Donovan, JL (Author) Other; Muir, K (Author) Other; Giles, GG (Author) Other; Severi, G (Author) Other; Wiklund, F (Author) Other; Gronberg, H (Author) Other; Haiman, CA (Author) Other; Schumacher, F (Author) Other; Henderson, BE (Author) Other; Le Marchand, L (Author) Other; Lindstrom, S (Author) Other; Kraft, P (Author) Other; Hunter, DJ (Author) Other; Gapstur, S (Author) Other; Chanock, SJ (Author) Other; Berndt, SI (Author) Other; Albanes, D (Author) Other; Andriole, G (Author) Other; Schleutker, J (Author) Other; Weischer, M (Author) Other; Canzian, F (Author) Other; Riboli, E (Author) Other; Key, TJ (Author) Other; Travis, RC (Author) Other; Campa, D (Author) Other; Ingles, SA (Author) Other; John, EM (Author) Other; Hayes, RB (Author) Other; Pharoah, PDP (Author) Other; Pashayan, N (Author) Other; Khaw, KT (Author) Other; Stanford, JL (Author) Other; Ostrander, EA (Author) Other; Signorello, LB (Author) Other; Thibodeau, SN (Author) Other; Schaid, D (Author) Other; Maier, C (Author) Other; Vogel, W (Author) Other; Kibel, AS (Author) Other; Cybulski, C (Author) Other; Lubhiski, J (Author) Other; Cannon Albright, L (Author) Other; Brenner, H (Author) Other; Park, JY (Author) Other; Kaneva, R (Author) Other; Batra, J (Author) Other; Spurdle, AB (Author) Other; Clements, JA (Author) Other; Manuel R Teixeira (Author) ICBAS; Dicks, E (Author) Other; Lee, A (Author) Other; Dunning, AM (Author) Other; Baynes, C (Author) Other; Conroy, D (Author) Other; Maranian, MJ (Author) Other; Ahmed, S (Author) Other; Govindasami, K (Author) Other; Guy, M (Author) Other; Wilkinson, RA (Author) Other; Sawyer, EJ (Author) Other; Morgan, A (Author) Other; Dearnaley, DP (Author) Other; Horwich, A (Author) Other; Huddart, RA (Author) Other; Khoo, VS (Author) Other; Parker, CC (Author) Other; Van As, NJ (Author) Other; Woodhouse, CJ (Author) Other; Thompson, A (Author) Other; Dudderidge, T (Author) Other; Ogden, C (Author) Other; Cooper, CS (Author) Other; Lophatananon, A (Author) Other; Cox, A (Author) Other; Southey, MC (Author) Other; Hopper, JL (Author) Other; English, DR (Author) Other; Aly, M (Author) Other; Adolfsson, J (Author) Other; Xu, JF (Author) Other; Zheng, SL (Author) Other; Yeager, M (Author) Other; Kaaks, R (Author) Other; Diver, WR (Author) Other; Gaudet, MM (Author) Other; Stern, MC (Author) Other; Corral, R (Author) Other; Joshi, AD (Author) Other; Shahabi, A (Author) Other; Wahlfors, T (Author) Other; Tammela, TLJ (Author) Other; Auvinen, A (Author) Other; Virtamo, J (Author) Other; Klarskov, P (Author) Other; Nordestgaard, BG (Author) Other; Roder, MA (Author) Other; Nielsen, SF (Author) Other; Bojesen, SE (Author) Other; Siddiq, A (Author) Other; FitzGerald, LM (Author) Other; Kolb, S (Author) Other; Kwon, EM (Author) Other; Karyadi, DM (Author) Other; Blot, WJ (Author) Other; Zheng, W (Author) Other; Cai, QY (Author) Other; McDonnell, SK (Author) Other; Rinckleb, AE (Author) Other; Drake, B (Author) Other; Colditz, G (Author) Other; Wokolorczyk, D (Author) Other; Stephenson, RA (Author) Other; Teerlink, C (Author) Other; Muller, H (Author) Other; Rothenbacher, D (Author) Other; Sellers, TA (Author) Other; Lin, HY (Author) Other; Slavov, C (Author) Other; Mitev, V (Author) Other; Lose, F (Author) Other; Srinivasan, S (Author) Other; Maia, S (Author) Other; Paulo, P (Author) Other; Lange, E (Author) Other; Cooney, KA (Author) Other; Antoniou, AC (Author) Other; Vincent, D (Author) Other; Bacot, F (Author) Other; Tessier, DC (Author) Other; Kote Jarai, Z (Author) Other; Easton, DF (Author) Other

Journal

Title: Nature Genetics

Vol. 45

Pages: 385-391

ISSN: 1061-4036

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 418 Citations

Scopus - 431 Citations

Other information

Authenticus ID: P-005-27Q

DOI: 10.1038/ng.2560

Abstract (EN): Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom II lumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genomewide significance (P < 5 x 10(-8)). More than 70 prostate cancer susceptibility loci, explaining similar to 30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7