Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Kote Jarai, Z (Author) Other; Saunders, EJ (Author) Other; Leongamornlert, DA (Author) Other; Tymrakiewicz, M (Author) Other; Dadaev, T (Author) Other; Jugurnauth Little, S (Author) Other; Ross Adams, H (Author) Other; Al Olama, AA (Author) Other; Benlloch, S (Author) Other; Halim, S (Author) Other; Russel, R (Author) Other; Dunning, AM (Author) Other; Luccarini, C (Author) Other; Dennis, J (Author) Other; Neal, DE (Author) Other; Hamdy, FC (Author) Other; Donovan, JL (Author) Other; Muir, K (Author) Other; Giles, GG (Author) Other; Severi, G (Author) Other; Wiklund, F (Author) Other; Gronberg, H (Author) Other; Haiman, CA (Author) Other; Schumacher, F (Author) Other; Henderson, BE (Author) Other; Le Marchand, L (Author) Other; Lindstrom, S (Author) Other; Kraft, P (Author) Other; Hunter, DJ (Author) Other; Gapstur, S (Author) Other; Chanock, S (Author) Other; Berndt, SI (Author) Other; Albanes, D (Author) Other; Andriole, G (Author) Other; Schleutker, J (Author) Other; Weischer, M (Author) Other; Canzian, F (Author) Other; Riboli, E (Author) Other; Key, TJ (Author) Other; Travis, RC (Author) Other; Campa, D (Author) Other; Ingles, SA (Author) Other; John, EM (Author) Other; Hayes, RB (Author) Other; Pharoah, P (Author) Other; Khaw, KT (Author) Other; Stanford, JL (Author) Other; Ostrander, EA (Author) Other; Signorello, LB (Author) Other; Thibodeau, SN (Author) Other; Schaid, D (Author) Other; Maier, C (Author) Other; Vogel, W (Author) Other; Kibel, AS (Author) Other; Cybulski, C (Author) Other; Lubinski, J (Author) Other; Cannon Albright, L (Author) Other; Brenner, H (Author) Other; Park, JY (Author) Other; Kaneva, R (Author) Other; Batra, J (Author) Other; Spurdle, A (Author) Other; Clements, JA (Author) Other; Manuel R Teixeira (Author) ICBAS; Govindasami, K (Author) Other; Guy, M (Author) Other; Wilkinson, RA (Author) Other; Sawyer, EJ (Author) Other; Morgan, A (Author) Other; Dicks, E (Author) Other; Baynes, C (Author) Other; Conroy, D (Author) Other; Bojesen, SE (Author) Other; Kaaks, R (Author) Other; Vincent, D (Author) Other; Bacot, F (Author) Other; Tessier, DC (Author) Other; Easton, DF (Author) Other; Eeles, RA (Author) Other

Journal

Title: Human Molecular Genetics

Vol. 22

Pages: 2520-2528

ISSN: 0964-6906

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 85 Citations

Scopus - 87 Citations

Other information

Authenticus ID: P-005-008

DOI: 10.1093/hmg/ddt086

Abstract (EN): Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate the association between genetic variation across this region and PrCa, we performed a fine-mapping analysis by genotyping 134 SNPs using a custom Illumina iSelect array or Sequenom MassArray iPlex, followed by imputation of 1094 SNPs in 22 301 PrCa cases and 22 320 controls in The PRACTICAL consortium. Multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of TERT that independently associated with PrCa risk. Gene expression analysis of normal prostate tissue showed evidence that SNPs within one of these regions also associated with TERT expression, providing a potential mechanism for predisposition to disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9