Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Manuel R Teixeira (Author) ICBAS; Ribeiro, FR (Author) Other; Torres, L (Author) Other; Pandis, N (Author) Other; Andersen, JA (Author) Other; Lothe, RA (Author) Other; Heim, S (Author) Other

Journal

Title: British Journal of Cancer

Vol. 91

Pages: 775-782

ISSN: 0007-0920

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 54 Citations

Scopus - 56 Citations

Other information

Authenticus ID: P-000-8ZQ

DOI: 10.1038/sj.bjc.6602021

Abstract (EN): The issue of whether multiple, ipsilateral or bilateral, breast carcinomas represent multiple primary tumours or dissemination of a single carcinomatous process has been difficult to resolve, especially for individual patients. We have addressed the problem by comparative genomic hybridisation analysis of 26 tumours from 12 breast cancer patients with multiple ipsilateral and/or bilateral carcinoma lesions. Genomic imbalances were detected in 25 of the 26 (96%) tumours. Using the genomic imbalances detected in these 26 lesions as well as those previously found by us in an independent series of 35 unifocal breast carcinomas, we compared a probabilistic model for likelihood of independence with unsupervised hierarchical clustering methodologies to determine the clonal relatedness of multiple tumours in breast cancer patients. We conclude that CGH analysis of multiple breast carcinomas followed by unsupervised hierarchical clustering of the genomic imbalances is more reliable than previous criteria to determine the tumours' clonal relationship in individual patients, that most ipsilateral breast carcinomas arise through intramammary spreading of a single breast cancer, and that most patients with bilateral breast carcinomas have two different diseases.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8