Multiple numerical chromosome aberrations in cancer: what are their causes and what are their consequences?

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

Manuel R Teixeira (Author) ICBAS; Heim, S (Author) Other

Journal

Title: Seminars in Cancer Biology

Vol. 15

Pages: 3-12

ISSN: 1044-579X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 33 Citations

Scopus - 35 Citations

Other information

Authenticus ID: P-000-4Z6

DOI: 10.1016/j.semcancer.2004.09.006

Abstract (EN): Several neoplastic tumor types are cytogenetically characterized by multiple numerical chromosome abnormalities without concomitant structural karyotypic changes. At present, no good gene-level theories are at hand to explain the pathogenetic effect of these changes during tumorigenesis. nor is it known how they arise or what causes them. Genetic instability is often invoked as an underlying cause. but actual data favoring this explanation are meager or non-existing. Numerical chromosome changes and ploidy shifts allow the simultaneous alteration of multiple cancer-relevant genes, thereby reducing the number of independent genomic events necessary for carcinogenesis and the need for postulating genomic instability as a necessity in cancer development.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10