Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Rebbeck, TR (Author) Other; Friebel, TM (Author) Other; Friedman, E (Author) Other; Hamann, U (Author) Other; Huo, DZ (Author) Other; Kwong, A (Author) Other; Olah, E (Author) Other; Olopade, OI (Author) Other; Solano, AR (Author) Other; Teo, SH (Author) Other; Thomassen, M (Author) Other; Weitzel, JN (Author) Other; Chan, TL (Author) Other; Couch, J (Author) Other; Goldgar, DE (Author) Other; Kruse, TA (Author) Other; Palmero, I (Author) Other; Park, SK (Author) Other; Torres, D (Author) Other; van Rensburg, EJ (Author) Other; McGuffog, L (Author) Other; Parsons, MT (Author) Other; Leslie, G (Author) Other; Aalfs, CM (Author) Other; Abugattas, J (Author) Other; Adlard, J (Author) Other; Agata, S (Author) Other; Aittomaki, K (Author) Other; Andrews, L (Author) Other; Andrulis, IL (Author) Other; Arason, A (Author) Other; Arnold, N (Author) Other; Arun, BK (Author) Other; Asseryanis, E (Author) Other; Auerbach, L (Author) Other; Azzollini, J (Author) Other; Balmana, J (Author) Other; Barile, M (Author) Other; Barkardottir, RB (Author) Other; Barrowdale, D (Author) Other; Benitez, J (Author) Other; Berger, A (Author) Other; Berger, R (Author) Other; Blanco, AM (Author) Other; Blazer, KR (Author) Other; Blok, MJ (Author) Other; Bonadona, V (Author) Other; Bonanni, B (Author) Other; Bradbury, AR (Author) Other; Brewer, C (Author) Other; Buecher, B (Author) Other; Buys, SS (Author) Other; Caldes, T (Author) Other; Caliebe, A (Author) Other; Caligo, MA (Author) Other; Campbell, I (Author) Other; Caputo, SM (Author) Other; Chiquette, J (Author) Other; Chung, WK (Author) Other; Claes, KBM (Author) Other; Collee, JM (Author) Other; Cook, J (Author) Other; Davidson, R (Author) Other; de la Hoya, M (Author) Other; De Leeneer, K (Author) Other; de Pauw, A (Author) Other; Delnatte, C (Author) Other; Diez, O (Author) Other; Ding, YC (Author) Other; Ditsch, N (Author) Other; Domchek, S (Author) Other; Dorfling, CM (Author) Other; Velazquez, C (Author) Other; Dworniczak, B (Author) Other; Eason, J (Author) Other; Easton, DF (Author) Other; Eeles, R (Author) Other; Ehrencrona, H (Author) Other; Ejlertsen, B (Author) Other; Engel, C (Author) Other; Engert, S (Author) Other; Evans, DG (Author) Other; Faivre, L (Author) Other; Feliubadalo, L (Author) Other; Ferrer, SF (Author) Other; Foretova, L (Author) Other; Fowler, J (Author) Other; Frost, D (Author) Other; Galvao, HCR (Author) Other; Ganz, PA (Author) Other; Garber, J (Author) Other; Gauthier Villars, M (Author) Other; Gehrig, A (Author) Other; Gerdes, AM (Author) Other; Gesta, P (Author) Other; Giannini, G (Author) Other; Giraud, S (Author) Other; Glendon, G (Author) Other; Godwin, AK (Author) Other; Greene, MH (Author) Other; Gronwald, J (Author) Other; Gutierrez Barrera, A (Author) Other; Hahnen, E (Author) Other; Hauke, J (Author) Other; Henderson, A (Author) Other; Hentschel, J (Author) Other; Hogervorst, FBL (Author) Other; Honisch, E (Author) Other; Imyanitov, EN (Author) Other; Isaacs, C (Author) Other; Izatt, L (Author) Other; Izquierdo, A (Author) Other; Jakubowska, A (Author) Other; James, P (Author) Other; Janavicius, R (Author) Other; Jensen, UB (Author) Other; John, EM (Author) Other; Vijai, J (Author) Other; Kaczmarek, K (Author) Other; Karlan, BY (Author) Other; Kast, K (Author) Other; Kim, SW (Author) Other; Konstantopoulou, I (Author) Other; Korach, J (Author) Other; Laitman, Y (Author) Other; Lasa, A (Author) Other; Lasset, C (Author) Other; Lazaro, C (Author) Other; Lee, A (Author) Other; Lee, MH (Author) Other; Lester, J (Author) Other; Lesueur, F (Author) Other; Liljegren, A (Author) Other; Lindor, NM (Author) Other; Longy, M (Author) Other; Loud, JT (Author) Other; Lu, KH (Author) Other; Lubinski, J (Author) Other; Machackova, E (Author) Other; Manoukian, S (Author) Other; Mari, V (Author) Other; Martinez Bouzas, C (Author) Other; Matrai, Z (Author) Other; Mebirouk, N (Author) Other; Meijers Heijboer, HEJ (Author) Other; Meindl, A (Author) Other; Mensenkamp, AR (Author) Other; Mickys, U (Author) Other; Miller, A (Author) Other; Montagna, M (Author) Other; Moysich, KB (Author) Other; Mulligan, AM (Author) Other; Musinsky, J (Author) Other; Neuhausen, SL (Author) Other; Nevanlinna, H (Author) Other; Ngeow, J (Author) Other; Nguyen, HP (Author) Other; Niederacher, D (Author) Other; Nielsen, HR (Author) Other; Nielsen, FC (Author) Other; Nussbaum, RL (Author) Other; Offit, K (Author) Other; Ofverholm, A (Author) Other; Ong, KR (Author) Other; Osorio, A (Author) Other; Papi, L (Author) Other; Papp, J (Author) Other; Pasini, B (Author) Other; Pedersen, IS (Author) Other; Peixoto, A (Author) Other; Peruga, N (Author) Other; Peterlongo, P (Author) Other; Pohl, E (Author) Other; Pradhan, N (Author) Other; Prajzendanc, K (Author) Other; Prieur, F (Author) Other; Pujol, P (Author) Other; Radice, P (Author) Other; Ramus, SJ (Author) Other; Rantala, J (Author) Other; Rashid, MU (Author) Other; Rhiem, K (Author) Other; Robson, M (Author) Other; Rodriguez, GC (Author) Other; Rogers, MT (Author) Other; Rudaitis, V (Author) Other; Schmidt, AY (Author) Other; Schmutzler, RK (Author) Other; Senter, L (Author) Other; Shah, PD (Author) Other; Sharma, P (Author) Other; Side, LE (Author) Other; Simard, J (Author) Other; Singer, CF (Author) Other; Skytte, AB (Author) Other; Slavin, TP (Author) Other; Snape, K (Author) Other; Sobol, H (Author) Other; Southey, M (Author) Other; Steele, L (Author) Other; Steinemann, D (Author) Other; Sukiennicki, G (Author) Other; Sutter, C (Author) Other; Szabo, CI (Author) Other; Tan, YY (Author) Other; Manuel R Teixeira (Author) ICBAS; Terry, MB (Author) Other; Teule, A (Author) Other; Thomas, A (Author) Other; Thull, DL (Author) Other; Tischkowitz, M (Author) Other; Tognazzo, S (Author) Other; Toland, AE (Author) Other; Topka, S (Author) Other; Trainer, AH (Author) Other; Tung, N (Author) Other; van Asperen, CJ (Author) Other; van der Hout, AH (Author) Other; van der Kolk, LE (Author) Other; van der Luijt, RB (Author) Other; Van Heetvelde, M (Author) Other; Varesco, L (Author) Other; Varon Mateeva, R (Author) Other; Vega, A (Author) Other; Villarreal Garza, C (Author) Other; von Wachenfeldt, A (Author) Other; Walker, L (Author) Other; Wang Gohrke, S (Author) Other; Wappenschmidt, B (Author) Other; Weber, BHF (Author) Other; Yannoukakos, D (Author) Other; Yoon, SY (Author) Other; Zanzottera, C (Author) Other; Zidan, J (Author) Other; Zorn, KK (Author) Other; Selkirk, CGH (Author) Other; Hulick, PJ (Author) Other; Chenevix Trench, G (Author) Other; Spurdle, AB (Author) Other; Antoniou, AC (Author) Other; Nathanson, KL (Author) Other

Journal

Title: Human Mutation

Vol. 39

Pages: 593-620

ISSN: 1059-7794

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 141 Citations

Other information

Authenticus ID: P-00R-AD7

DOI: 10.1002/humu.23406

Abstract (EN): The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on White in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutations ascertained from 69 centers in 49 countries on six continents. This study comprehensively describes the characteristics of the 1,650 unique BRCA1 and 1,731 unique BRCA2 deleterious (disease-associated) mutations identified in the CIMBA database. We observed substantial variation in mutation type and frequency by geographical region and race/ethnicity. In addition to known founder mutations, mutations of relatively high frequency were identified in specific racial/ethnic or geographic groups that may reflect founder mutations and which could be used in targeted (panel) first pass genotyping for specific populations. Knowledge of the population-specific mutational spectrum in BRCA1 and BRCA2 could inform efficient strategies for genetic testing and may justify a more broad-based oncogenetic testing in some populations.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 28