Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Fevereiro Martins, M (Author) Other; Santos, AC (Author) Other; Marques Neves, C (Author) Other; Guimarães H (Author) FMUP; Bicho, M (Author) Other; GenE ROP Study Grp (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

ISSN: 0721-832X

Publisher: Springer

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00Y-FCG

DOI: 10.1007/s00417-023-06072-7

Abstract (EN): PurposeTo evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP).MethodsMulticenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed.ResultsA total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression.ConclusionIn our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10