Late Recurrence of Pancreatic Solid Pseudopapillary Neoplasm With Peritoneal Carcinomatosis Treated With Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Case Report

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Nogueiro, J (Author) FMUP; Gomes, F (Author) Other; Pacheco, J (Author) Other; Santos Sousa, H (Author) FMUP; Meireles, S (Author) Other; Melo, RB (Author) Other; Aral, M (Author) Other; Barbosa, E (Author) Other

Journal

Title: CUREUS JOURNAL OF MEDICAL SCIENCE

Vol. 14

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00X-FZB

DOI: 10.7759/cureus.31189

Abstract (EN): Pancreatic solid pseudopapillary neoplasm (SPN) is a rare malignant tumour predominantly affecting young women. The occurrence of peritoneal carcinomatosis (PC) in this setting is an even rarer condition, usually related to perioperative tumour rupture. We present a case of a 43-year-old woman who previously underwent distal splenopancreatectomy after the diagnosis of a pancreatic SPN. Thirteen years later, the patient underwent a radical hysterectomy due to a uterine myoma. Intraoperatively, a peritoneal mass was additionally found and resected. Histological examination revealed an implant with morphology compatible with pancreatic SPN. The patient was then referred to our institution. Staging MRI and CT revealed multiple nodular lesions adjacent to the left colon, suggestive of peritoneal implants. The patient was then submitted to cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin and irinotecan. Histological examination confirmed peritoneal involvement by a pancreatic SPN. The postoperative course was unremarkable. Two years after surgery, the patient remains asymptomatic with no evidence of relapse. Despite SPN being cancer with a relatively indolent evolution, one needs to be aware of a possible recurrence several years after the primary resection, mainly in patients with evidence of intraoperative tumour rupture.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4