Advances on diagnosis of Helicobacter pylori infections

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Sousa, C (Author) Other; Ferreira, R (Author) Other; Santos, SB (Author) Other; Azevedo, NF (Author) FEUP; Melo, LDR (Author) Other

Journal

Title: Critical Reviews in Microbiology

Vol. 49

Pages: 671-692

ISSN: 1040-841X

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00X-DY9

DOI: 10.1080/1040841x.2022.2125287

Abstract (EN): The association of Helicobacter pylori to several gastric diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer, and its high prevalence worldwide, raised the necessity to use methods for a proper and fast diagnosis and monitoring the pathogen eradication. Available diagnostic methods can be classified as invasive or non-invasive, and the selection of the best relies on the clinical condition of the patient, as well as on the sensitivity, specificity, and accessibility of the diagnostic test. This review summarises all diagnostic methods currently available, including the invasive methods: endoscopy, histology, culture, and molecular methods, and the rapid urease test (RUT), as well as the non-invasive methods urea breath test (UBT), serological assays, biosensors, and microfluidic devices and the stool antigen test (SAT). Moreover, it lists the diagnostic advantages and limitations, as well as the main advances for each methodology. In the end, research on the development of new diagnostic methods, such as bacteriophage-based H. pylori diagnostic tools, is also discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 22