Novel pyridine-2,4,6-tricarbohydrazide derivatives: Design, synthesis, characterization and in vitro biological evaluation as alpha- and beta-glucosidase inhibitors

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Riaz, S (Author) Other; Khan, IU (Author) Other; Yar, M (Author) Other; Ashraf, M (Author) Other; Rehman, TU (Author) Other; Shaukat, A (Author) Other; Jamal, SB (Author) Other; Duarte, VCM (Author) Other; Alves, MJ (Author) Other

Journal

Title: Bioorganic Chemistry

Vol. 57

Pages: 148-154

ISSN: 0045-2068

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-009-Z3K

DOI: 10.1016/j.bioorg.2014.10.007

Abstract (EN): A range of novel pyridine 2,4,6-tricarbohydrazide derivatives (4a-4h) were synthesized and its biological inhibition towards alpha- and beta-glucosidases was studied. Most of the compounds demonstrate to be active against a-glucosidase, and quite inactive/completely inactive against beta-glucosidase. A number of compounds were found to be more active against alpha-glucosidase than the reference compound acarbose (IC50 38.25 +/- 0.12 mu M); being compound 4d with the p-hydroxy phenyl motive the most active (IC50 20.24 +/- 0.72 mu M). Molecular modeling studies show the interactions of compound 4d with the active site of target alpha-glucosidase kinase.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7