Modulation of the Mechanisms Driving Transthyretin Amyloidosis

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Bezerra, F (Author) Other; Maria Joao Saraiva (Author) FMUP; Almeida, MR (Author) ICBAS

Journal

Title: Frontiers in Molecular Neuroscience

Vol. 13

ISSN: 1662-5099

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-00T-8Q3

DOI: 10.3389/fnmol.2020.592644

Abstract (EN): Transthyretin (TTR) amyloidoses are systemic diseases associated with TTR aggregation and extracellular deposition in tissues as amyloid. The most frequent and severe forms of the disease are hereditary and associated with amino acid substitutions in the protein due to single point mutations in the TTR gene (ATTRv amyloidosis). However, the wild type TTR (TTR wt) has an intrinsic amyloidogenic potential that, in particular altered physiologic conditions and aging, leads to TTR aggregation in people over 80 years old being responsible for the non-hereditary ATTRwt amyloidosis. In normal physiologic conditions TTR wt occurs as a tetramer of identical subunits forming a central hydrophobic channel where small molecules can bind as is the case of the natural ligand thyroxine (T-4). However, the TTR amyloidogenic variants present decreased stability, and in particular conditions, dissociate into partially misfolded monomers that aggregate and polymerize as amyloid fibrils. Therefore, therapeutic strategies for these amyloidoses may target different steps in the disease process such as decrease of variant TTR (TTRv) in plasma, stabilization of TTR, inhibition of TTR aggregation and polymerization or disruption of the preformed fibrils. While strategies aiming decrease of the mutated TTR involve mainly genetic approaches, either by liver transplant or the more recent technologies using specific oligonucleotides or silencing RNA, the other steps of the amyloidogenic cascade might be impaired by pharmacologic compounds, namely, TTR stabilizers, inhibitors of aggregation and amyloid disruptors. Modulation of different steps involved in the mechanism of ATTR amyloidosis and compounds proposed as pharmacologic agents to treat TTR amyloidosis will be reviewed and discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15