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Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries

Title
Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
Type
Another Publication in an International Scientific Journal
Year
2017
Authors
Gomes, J
(Author)
Other
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Mereiter, S
(Author)
Other
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Magalhaes, A
(Author)
Other
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Celso Reis
(Author)
ICBAS
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Journal
Title: Cancer CellImported from Authenticus Search for Journal Publications
Vol. 32
Pages: 544-545
ISSN: 1535-6108
Publisher: Elsevier
Other information
Authenticus ID: P-00N-7Y5
Abstract (EN): Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 2
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