Single Nucleotide Polymorphism in Prolactin Gene Is Associated With Clinical Aggressiveness and Outcome of Canine Mammary Malignant Tumors

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Canadas Sousa, A (Author) Other; Santos, M (Author) Other; Rui Medeiros (Author) ICBAS; Dias Pereira, P (Author) Other

Journal

Title: Veterinary Pathology

Vol. 58

Pages: 1051-1057

ISSN: 0300-9858

Publisher: SAGE

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-6BX

DOI: 10.1177/03009858211022705

Abstract (EN): Prolactin (PRL) is a key hormone involved in canine mammary development and tumorigenesis. In this study, the influence of a single nucleotide polymorphism (SNP) in the PRL gene (rs23932236) on the clinicopathological parameters and survival of dogs with canine mammary tumors (CMTs) was investigated. A total of 206 female dogs with spontaneous mammary tumors were enrolled in this study and circulating blood cells were genotyped. This specific SNP was associated with larger size (>3 cm diameter) for malignant tumors (P = .036), tumors with infiltrative/invasive growth pattern (P = .010), vascular invasion (P = .006), and lymph node metastasis (P = .004). Carriers of the variant allele had a shorter overall survival compared to the wild-type population with an overall survival of 18.7 months and 22.7 months, respectively (P = .004). These findings suggest that SNP rs23932236 of canine PRL gene may be used as an indicator for the development of clinically aggressive forms of CMTs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7