Leukocyte telomere length and hTERT genetic polymorphism rs2735940 influence the renal cell carcinoma clinical outcome

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Morais, M (Author) Other; Dias, F (Author) Other; Resende, T (Author) Other; Nogueira, I (Author) Other; Oliveira, J (Author) Other; Mauricio, J (Author) Other; Teixeira, AL (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Future Oncology

Vol. 16

Pages: 1245-1256

ISSN: 1479-6694

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00S-AMB

DOI: 10.2217/fon-2019-0795

Abstract (EN): Aim: Analysis of the genetic hTERT-1327 C>T (rs2735940) influence on leukocyte telomere length (LTL) and tumor development, progression and overall survival in renal cell carcinoma (RCC) patients. Materials & methods: Using leukocyte DNA of RCC patients and healthy individuals, LTL measurement and allelic discrimination of rs2735940 was performed by real-time PCR. Results: RCC patients showed shorter LTL than healthy individuals and LTL increased with clinical stage. CC+TC genotypes healthy carriers' presented shorter LTL. However, no statistical association between the different genotypes and RCC risk. Nevertheless, CC homozygous presented a reduced time to disease progression and a lower overall survival. The use of hTERT-1327 single nucleotide polymorphism information increased the capacity to predict risk for RCC progression. Conclusion: In fact, in healthy individuals, hTERT-1327 CC+TC genotypes were associated with shorter LTL, and this single nucleotide polymorphism was associated with time to disease progression, being a promising potential prognosis biomarker to be used in the future. Graphical abstract The potential of the genetic polymorphism hTERT-1327 C>T (rs2735940) as a prognosis biomarker and the influence of leucocyte telomere length in renal cell carcinoma (RCC). RCC patients showed shorter leucocyte telomere length than healthy individuals. CC+CT genotypes of hTERT-1327 C>T genetic polymorphism are associated with shorter telomeres in healthy individuals and RCC patients with CC genotype show shorter time to disease progression interval and worse overall survival.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12