Modern computational methods for rational enzyme engineering

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Ferreira, P (Author) Other; Pedro A Fernandes (Author) FCUP; Ramos, MJ (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: CHEM CATALYSIS

Vol. 2

Pages: 2481-2498

ISSN: 2667-1093

Indexing

ISI Web of Knowledge - 5 Citations

Scopus

Other information

Authenticus ID: P-00X-D5M

DOI: 10.1016/j.checat.2022.09.036

Abstract (EN): Biocatalysis is a thriving field of research because of the vast, environmentally friendly impact that enzymes have on industry and biotechnology. However, in most production lines, the use of enzymes is unfeasible as a result of low enzyme stability or low catalytic rates or simply because no enzyme catalyzes the desired reaction. Rational enzyme engineering promises to allow a widespread use of enzymes in industry, helping the transition to a greener economy. Computational methods are assuming an ever-growing role holding great value in guiding and rationalizing experimental campaigns and drastically improve their chances of success. We focus on the industrial and biotechnological applications of enzymes, on their potential to be of critical importance in the much-needed transition to a greener global economy, on the barriers preventing them from being attractive in many industrial fields, and on the role that computational prediction methods have had and will have to provide solutions to overcome them.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18