Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Rodrigues, JG (Author) Other; Balmana, M (Author) Other; Macedo, JA (Author) Other; Pocas, J (Author) Other; Maria Ângela Almeida (Author) FCUP; de Freitas Junior, JCM (Author) Other; Pinho, SS (Author) Other; Gomes, J (Author) Other; Magalhaes, A (Author) Other; Gomes, C (Author) Other; Mereiter, S (Author) Other; Celso Reis (Author) ICBAS

Journal

Title: Cellular Immunology

Vol. 333

Pages: 46-57

ISSN: 0008-8749

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 149 Citations

Scopus - 160 Citations

Other information

Authenticus ID: P-00N-T1M

DOI: 10.1016/j.cellimm.2018.03.007

Abstract (EN): Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate multi-step process that requires the acquisition of several cancer cell features, including the modulation of tumour cell migration, adhesion, invasion, and immune evasion. Changes in the cellular glycosylation are associated with malignant transformation of cancer cells, tumour progression and ultimately, metastasis formation. Glycans have major impact on cellular signalling and on the regulation of tumour cell-cell adhesion and cell-matrix interaction. Glycans drive the interplay between the cancer cells and the tumour microenvironment. In this review, we summarize the roles of glycan alterations in tumour progression, such as acquisition of oncogenic features due to modulation of receptor tyrosine kinases, proteoglycans, cadherins and integrins. We also highlight the importance of key glycan binding proteins such as selectins, siglecs and galectins, which are pivotal in the modulation of immune response. An overview on glycans as cancer biomarkers is also presented.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12