The archaeal non-heme iron-containing Sulfur Oxygenase Reductase

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Ferreira, P (Author) Other; Pedro A Fernandes (Author) FCUP; Ramos, MJ (Author) Other

Journal

Title: Coordination Chemistry Reviews

Vol. 455

ISSN: 0010-8545

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-00W-05V

DOI: 10.1016/j.ccr.2021.214358

Abstract (EN): The importance of metal containing catalytic sites are one of the pillars of life due to the crucial redox chemistry they allow. In an extreme environment, where increasingly more organisms are known to thrive, mostly from the Archaea domain, metals promote the growth of the existent living beings. One metabolic route in which metal containing enzymes intervene is the sulfur oxidation pathway. A fundamental process for the thermoacidophile and hyperthermoacidophile organisms that also has interesting potential biotechnological applications, particularly in the biomining field. In this paper, we approach the first enzyme of the sulfur oxidation pathway in Archaea, the sulfur oxygenase reductase (SOR). It is a non-heme iron containing enzyme, possessing a 2-His-1-carboxylate motif coordinating the iron. This enzyme can reduce and oxidize elemental sulfur every reaction cycle. Structurally, SOR is a well described enzyme but the knowledge regarding its catalytic mechanism has many gaps. The detailed description of the subtleties of the catalytic reaction of SOR should stimulate further exploration of its biotechnological potentials as it allows the rational engineering of the enzyme to tune it to a desirable function and efficiency.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10